The influence of nanostructured features on bacterial adhesion and bone cell functions on severely shot peened 316L stainless steel.

Substrate grain structure and topography play major roles in mediating cell and bacteria activities. Severe plastic deformation techniques, known as efficient metal-forming and grain refining processes, provide the treated material with novel mechanical properties and can be adopted to modify nanoscale surface characteristics, possibly affecting interactions with the biological environment. This in vitro study evaluates the capability of severe shot peening, based on severe plastic deformation, to modulate the interactions of nanocrystallized metallic biomaterials with cells and bacteria.

Osteoblast and monocyte responses to 444 ferritic stainless steel intended for a magneto-mechanically actuated fibrous scaffold.

The rationale behind this work is to design an implant device, based on a ferromagnetic material, with the potential to deform in vivo promoting osseointegration through the growth of a healthy periprosthetic bone structure. One of the primary requirements for such a device is that the material should be non-inflammatory and non-cytotoxic. In the study described here, we assessed the short-term cellular response to 444 ferritic stainless steel; a steel, with a very low interstitial content and a small amount of strong carbide-forming elements to enhance intergranular corrosion resistance.

New poly(epsilon-caprolactone)/chitosan blend fibers for tissue engineering applications.

This study reports for the first time on the production of poly(epsilon-caprolactone)/chitosan blend fibers for future application as tissue engineering scaffolds. Fibers of chitosan and poly(epsilon-caprolactone) were prepared by wet spinning from blend solutions, using a formic acid/acetone 70:30vol.% mixture as common solvent and methanol as coagulant.