Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice.

DMSO has been many times described as harmless substance, beneficial in various diseases or pathological states, including brain injury or ischemia. Using Lurcher mutant mice suffering from genetically determined olivocerebellar degeneration and normal wild type mice, we examined the effect of DMSO on spontaneous motor activity and spatial learning and orientation ability. The acute effect of DMSO was studied in mice aged 3, 6, 9 and 22 weeks.

Metal, EMF, and brain energy metabolism.

Some implications of cooperative potential of metal ions and electromagnetic fields' radiation (EMF) in carcinogenic processes are discussed. It is known that these factors, chemical and physical individually have connections with processes of oxidative stress. Special attention was paid to possible manifestation within the brain.

[Microscopical examination in the neuropathophysiological research].

Microscopical examination of brain tissue appears as a valuable process, which can acknowledge, complete or confute the acquired findings by functional experiments. The purpose of this work was to survey histo-morphological and functio-morphological techniques mostly used in the neuropathophysiological research with application examples. The most common pathological processes in the brain is possible to document with some of this methods.