Publications by authors named "Vera I Egorova"
Article Synopsis
- - The study investigates how simple DNA repeat expansions contribute to hereditary disorders like Friedreich's ataxia, focusing on whether replication or transcription plays a bigger role in this process.
- - The researchers created two yeast genetic systems to compare repeat expansions in both transcribed and non-transcribed regions, discovering that large expansions can happen without transcription and that transcription significantly increases the rate of expansions.
- - They propose a model suggesting that the transcriptional state of DNA, influenced by nucleosomal density, regulates the frequency of large-scale repeat expansions, with replication defects also boosting these rates regardless of transcription.
