GeneNetTools: tests for Gaussian graphical models with shrinkage.

Motivation: Gaussian graphical models (GGMs) are network representations of random variables (as nodes) and their partial correlations (as edges). GGMs overcome the challenges of high-dimensional data analysis by using shrinkage methodologies. Therefore, they have become useful to reconstruct gene regulatory networks from gene-expression profiles.

Distinguishing Patients With a Coordination Disorder From Healthy Controls Using Local Features of Movement Trajectories During the Finger-to-Nose Test.

Assessment of coordination disorders is valuable for monitoring progression of patients, distinguishing healthy and pathological conditions, and ultimately aiding in clinical decision making, thereby offering the possibility to improve medical care or rehabilitation. A common method to assess movement disorders is by using clinical rating scales. However, rating scales depend on the evaluation and interpretation of an observer, implying that subjective phenotypic assignment precedes the application of the scales.

Assessing Dynamic Balance Performance During Exergaming Based on Speed and Curvature of Body Movements.

Improving balance performance among the elderly is of utmost importance because of the increasing number of injuries and fatalities caused by fall incidences. Digital games controlled by body movements (exergames) have been proposed as a way to improve balance among older people. However, the assessment of balance performance in real-time during exergaming remains a challenging task.

Visual Data Exploration for Balance Quantification in Real-Time During Exergaming.

Unintentional injuries are among the ten leading causes of death in older adults; falls cause 60% of these deaths. Despite their effectiveness to improve balance and reduce the risk of falls, balance training programs have several drawbacks in practice, such as lack of engaging elements, boring exercises, and the effort and cost of travelling, ultimately resulting in low adherence. Exergames, that is, digital games controlled by body movements, have been proposed as an alternative to improve balance.