Publications by authors named "Venugopala R Mekala"
Front Genet
September 2024
Article Synopsis
- Researchers sequenced the genomes of 321 male gout patients and additional controls to identify rare variants (RVs) linked to gout, finding 682 significant RVs clustered on various chromosomes.
- Notably, three rare variants (rs559954634, rs186763678, and 13-85340782-G-A) were identified for the first time in relation to gout in Taiwanese males, with rs559954634 showing a significant positive effect.
- The study suggests that these RVs, particularly rs559954634 which influences uric acid regulation, may be crucial for understanding gout susceptibility, warranting further research into their mechanisms.
Article Synopsis
- - The widespread use of copper oxide nanoparticles (CuO-NPs) in industries has raised environmental concerns due to their accumulation and potential toxic effects on living organisms, including humans.
- - A study was conducted using female albino Wistar rats to evaluate the toxicity of CuO-NPs through single acute doses and multiple subacute doses, following standardized OECD guidelines.
- - Results indicated that higher doses led to significant biochemical and histopathological changes in the liver, kidney, and brain, suggesting that the toxicity might be linked to an increase in reactive oxygen species generated by CuO-NPs.
