Quorum quenching effects of linoleic and stearic acids on outer membrane vesicle-mediated virulence in .

is a pathogenic bacterium that can infect humans and animals, yet the role of its outer membrane vesicles (OMVs) in mediating pathogenicity remains underexplored. This study evaluated the effects of linoleic acid (LA) and stearic acid (SA) on quorum sensing (QS)-mediated violacein production, biofilm formation, and OMV biogenesis in . Our findings revealed that 2 mM LA and 1 mM SA effectively quench QS, leading to a significant reduction in violacein production, biofilm formation, and OMV biogenesis.

Quorum quenching mediated biofilm impediment in and by leaf extracts of .

Biofilms are complex communities of microorganisms that cause systemic infections, resistance development and delay in healing wounds. Biofilms can form in various parts of the human body, such as the teeth, lungs, urinary tract, and wounds. Biofilm complicates the effects of antibiotics in treating infections.

Regulation of virulence in and strategies to combat it.

is a rod-shaped, Gram-negative, facultatively anaerobic bacteria with a cosmopolitan distribution. Just about 160 incidents have been reported globally, but then once infected, it has the ability to cause deadly septicemia, and infections in the lungs, liver, brain, spleen, and lymphatic systems that might lead to death. produces and utilizes violacein to kill bacteria that compete with it in an ecological niche.

A critical role of farnesol in the modulation of Amphotericin B and Aureobasidin A antifungal drug susceptibility.

and its related species can cause opportunistic infections such as "candidiasis" in immunocompromised individuals with a high morbidity and mortality rate. Several antifungal drugs available in the market are often used to treat infections caused by pathogenic fungi. However, in fungi, the development of resistance against these drugs quickly evolved.