Publications by authors named "Venkateshwar Polsani"

Article Synopsis
  • - The FUTURE-AS Registry is a study designed to evaluate the effectiveness and safety of using computed tomography coronary angiography (CTCA) and fractional flow reserve (FFR) for assessing coronary artery disease (CAD) in patients with severe aortic stenosis (AS) who are candidates for transcatheter aortic valve replacement (TAVR).
  • - The study will measure key outcomes such as the accuracy of CTCA and FFR in detecting significant CAD compared to traditional methods, as well as the safety of the procedures with respect to potential complications.
  • - By exploring the feasibility of these imaging techniques, the registry aims to determine if they can help reduce unnecessary invasive procedures before TAVR, ultimately improving patient care.
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Article Synopsis
  • The SCMR Registry is a comprehensive database that collects clinical data from cardiovascular magnetic resonance (CMR) exams, supporting research on treatment outcomes and advancing machine learning in cardiovascular health.
  • As of now, it contains data from over 154,000 CMR scans across 20 sites in the U.S., including a vast 100 terabytes of imaging data, revealing demographics such as an average patient age of 58 and a notable 8% mortality rate in the studied cohort.
  • Significant findings indicate a higher mortality risk associated with certain indicators, such as a left ventricular ejection fraction below 35% and specific wall motion abnormalities, showcasing the registry’s potential to enhance clinical insight and improve patient outcomes.
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  • Coronary artery occlusion (CO) is a serious complication during transcatheter aortic valve replacement (TAVR) and this study aimed to evaluate a predictive modeling algorithm to improve risk assessment during the planning phase.
  • During the study period, 116 patients identified as at higher risk for CO were analyzed using computational modeling to guide procedural adjustments, leading to various modifications like intentional laceration and the use of chimney stents.
  • Ultimately, no instances of coronary artery compromise occurred in either the high-risk patients with modifications or the low-risk group, indicating that predictive modeling significantly enhances TAVR planning effectiveness.
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  • Patients with bicuspid aortic valve (BAV) often experience aortic stenosis and aortopathy, but their aortic arch geometry has been poorly quantified, leading to subjective clinical classifications.
  • This study analyzed 3D aortic arch and BAV geometry using pre-TAVR computed tomography in 59 patients, focusing on various morphological features of the valve and the aortic structure.
  • Results showed a bimodal distribution of valve shapes, complex 3D variations in aortic arch geometry, and established quantitative subgroups based on curvature and area changes, enhancing understanding of aortic geometry in BAV and aortic stenosis.
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Introduction: Percutaneous left atrial appendage occlusion (LAAO) is traditionally performed under general anesthesia with trans-esophageal echocardiography guidance. Intracardiac echo (ICE)-guided LAAO closure is increasing in clinical use. The ICE catheter is crossed into LA via interatrial septum (IAS) after the septum is dilated with LAAO delivery sheath.

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Article Synopsis
  • The study aimed to create an artificial intelligence (AI) model that predicts post-transcatheter aortic valve replacement (TAVR) outcomes, specifically the pressure gradient and aortic valve area, using pre-surgery echocardiography and CT data.
  • Researchers analyzed data from over 1,000 patients, dividing them into training and testing groups to develop and validate the AI models for accurate predictions.
  • Results showed that the AI model had a mean absolute error of 3.0 mm Hg for pressure gradients and 0.45 cm for aortic valve area, highlighting key predictors such as valve sheath size and age for pressure gradients, and left ventricular ejection fraction for aortic valve area.
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Transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve disease (BAV) has potential risks of under expansion and non-circularity which may compromise long-term durability. This study aims to investigate calcium fracture and balloon over expansion in balloon-expandable TAVs on the stent deformation with the aid of simulation. BAV patients treated with the SAPIEN 3 Ultra with pre- and post-TAVR CTs were analyzed (n = 8).

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Background: Quantitative cardiac magnetic resonance (CMR) outcome studies in aortic regurgitation (AR) are few. It is unclear if volume measurements are beneficial over diameters.

Objectives: This study sought to evaluate the association of CMR quantitative thresholds and outcomes in AR patients.

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Background: Left ventricular (LV) ischemia has been variably associated with functional mitral regurgitation (FMR). Determinants of FMR in patients with ischemia are poorly understood.

Objectives: This study sought to test whether contractile mechanics in ischemic myocardium underlying the mitral valve have an impact on likelihood of FMR.

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Accurate reconstruction of transcatheter aortic valve (TAV) geometries and other stented cardiac devices from computed tomography (CT) images is challenging, mainly associated with blooming artifacts caused by the metallic stents. In addition, bioprosthetic leaflets of TAVs are difficult to segment due to the low signal strengths of the tissues. This paper describes a method that exploits the known device geometry and uses an image registration-based reconstruction method to accurately recover the in vivo stent and leaflet geometries from patient-specific CT images.

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Objectives: The goal of this study was to test whether ischemia-mediated contractile dysfunction underlying the mitral valve affects functional mitral regurgitation (FMR) and the prognostic impact of FMR.

Background: FMR results from left ventricular (LV) remodeling, which can stem from myocardial tissue alterations. Stress cardiac magnetic resonance can assess ischemia and infarction in the left ventricle and papillary muscles; relative impact on FMR is uncertain.

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Importance: Stress cardiac magnetic resonance imaging (CMR) is not widely used in current clinical practice, and its ability to predict patient mortality is unknown.

Objective: To determine whether stress CMR is associated with patient mortality.

Design, Setting, And Participants: Real-world evidence from consecutive clinically ordered CMR examinations.

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Sarcoidosis is a systemic granulomatous disease that frequently involves the myocardium. Unfortunately, the sentinel manifestations of cardiac sarcoidosis are often potentially fatal bradyarrhythmia and tachyarrhythmia. Advanced imaging modalities such as cardiac magnetic resonance have allowed for increased diagnosis of cardiac involvement.

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Background: The purpose of this analysis is to describe the differences in cardiac magnetic resonance characteristics between benign and malignant tumors, which would be helpful for surgical planning.

Methods: This was a prospective cohort study of 130 patients who underwent cardiac magnetic resonance imaging for evaluation of a suspected cardiac mass. After excluding thrombi and tumors without definitive diagnosis, 66 tumors were evaluated for morphologic features and tissue composition.

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Background: Providers' understanding of the 2013 American College of Cardiology (ACC)/American Heart Association (AHA) cholesterol guideline in clinical practice is not known.

Methods: We designed a questionnaire, which was administered to internal medicine, family practice, cardiology, and endocrinology providers at 21 venues across the United States. We compared responses between providers in training or practice and between specialists (cardiology and endocrinology) and nonspecialists (internal medicine and family practice).

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Single coronary artery (SCA) is a very rare finding. Although most cases of SCA are found incidentally on coronary angiography, it can potentially lead to different clinical repercussions.1, 2 Herein we describe a patient with SCA who had unstable angina with subsequent sudden cardiac arrest, and we provide a brief review of the recent literature.

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Background: An accurate subtype classification of acute ischemic stroke is important in clinical practice as it can greatly influence patient care in terms of acute management and devising secondary stroke prevention strategies. Approximately, one third of ischemic strokes are cryptogenic despite a comprehensive workup. Diagnostic workup for detecting cardioaortic sources of cerebral embolism commonly includes transthoracic echocardiography (TTE).

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Purpose Of Review: To review the current literature on prosthetic valve function and para-valvular regurgitation (PVR) after trans-catheter aortic valve replacement (TAVR). TAVR is a new alternative for the treatment of severe aortic stenosis in patients at high risk for surgical aortic valve replacement and nonsurgical candidates.

Recent Findings: The innovations in three-dimensional trans-esophageal echocardiography have made it an integral part of the TAVR procedure.

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Left main coronary artery (LMCA) disease caused by external compression by a dilated main pulmonary artery (MPA) is an uncommon clinical entity but is one of the reversible causes of chest pain in patients with pulmonary hypertension. Traditionally, treatment of LMCA disease involves coronary artery bypass graft surgery. However, for LMCA compression by a dilated MPA, coronary angioplasty with stenting has recently been reported to have good outcomes and might be more suitable in some patients with high risk associated with surgery.

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