Publications by authors named "Venkatesh Kandula"
Asian Pac J Cancer Prev
August 2016
Article Synopsis
- Dual inhibition of kinases and angiogenesis is a more effective treatment strategy for medullary thyroid carcinoma (MTC) compared to targeting these processes individually, despite the risk of serious side effects.
- This study focuses on identifying dual inhibitors that can target RET and VEGFR2, using established inhibitors as a reference to find similar compounds with high affinity for both proteins.
- The compound AGN-PC-0CUK9P is highlighted as a promising candidate, showing equal affinity for RET and VEGFR2, good interaction properties, and favorable drug metabolism characteristics, warranting further pharmacodynamic and pharmacokinetic evaluation.
