Publications by authors named "Venkatesh Bukkapatnam"

A liquid chromatographic method has been established for the separation of five presently existing anti-diabetic drugs-metformin, pioglitazone, glibenclamide, glimepiride and repaglinide using design of experiments methodology. The main objective of this method is to identify the suitable conditions for the adequate separation of these five drugs with minimal analysis time. Experiment design is one of the Quality by design approaches, which incorporates multifaceted combinations of independent variables and their interactions during the optimization of analytical methods for the determination of drugs.

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Purpose: A simple stability indicating reverse phase liquid chromatographic method was developed for the simultaneous determination of rosuvastatin and ezetimibe in pharmaceutical formulations.

Methods: Best chromatographic response was achieved with C18 column (250 X 4.6 mm, 5µm) with photo diode array (PDA) detector.

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Febuxostat is a selective inhibitor of xanthine oxidase that is used for the treatment of hyperuricaemia in patients with gout. An isocratic liquid chromatographic method was developed and validated for the determination of febuxostat. Chromatographic separation was achieved on a C18 column using sodium acetate buffer (pH 4.

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