Biologically active filtration (BAF) for metabolic 1,4-dioxane removal from contaminated groundwater.

1,4-Dioxane is a persistent contaminant that is not effectively removed by conventional water treatment processes. In this study, bench-scale granular activated carbon (GAC)-based biologically active filtration (BAF) systems were developed to metabolically degrade 1,4-dioxane at environmentally relevant levels (<1000 μg L). BAF was established using predeveloped biologically activated carbon particles by mixing a 1,4-dioxane-degrading microbial community with granular activated carbon.

5-Chlorosalicylaldehyde Based New Chromo-Fluorogenic Schiff base Probes for Cu(II), Mn(II), CN, S and CO ions - Appositeness in Bioimaging and Molecular Logic Gate.

Two new multifunctional fluorescent Schiff base chemosensors 2,2'-(4-chlorophenyl)methylene)bis(azanylylidene))bis(methanylylidene))bis(4-chlorophenol) (CSCB) and 2,2'-(4-methoxyphenyl)methylene)bis(azanylylidene))bis(methanylylidene))bis(4-chlorophenol) (CSMB) were synthesized by following solvent free one pot synthesis approach for the colorimetric detection of Cu(II), Mn(II), CO, S and CN ions. The Schiff base chemosensors showed a colorimetric response towards the ions, where there was appearance of yellow color over colorless Schiff base solution. The detection process was accomplished by absorption and emission methods in aqueous methanol medium.

Accumulation and trophic transfer of per- and polyfluoroalkyl substances (PFAS) in estuarine organisms determined via stable isotopes.

Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants in estuaries. In this study, 19 PFAS were quantified in surface waters, sediments, marine invertebrates (aquatic worms, Eastern oysters, and blue crab), and forage fish (Atlantic silverside, four-spine stickleback, mummichog, sheepshead minnow, and rainwater killifish) in an aqueous film forming foam (AFFF)-contaminated estuary, Georgica Pond (NY, USA). Carbon and nitrogen stable isotopes (δC and δN) were used to determine trophic position of organisms and to identify modes of PFAS exposure.

Extreme events in the Higgs oscillator: A dynamical study and forecasting approach.

Many dynamical systems exhibit unexpected large amplitude excursions in the chronological progression of a state variable. In the present work, we consider the dynamics associated with the one-dimensional Higgs oscillator, which is realized through gnomonic projection of a harmonic oscillator defined on a spherical space of constant curvature onto a Euclidean plane, which is tangent to the spherical space. While studying the dynamics of such a Higgs oscillator subjected to damping and an external forcing, various bifurcation phenomena, such as symmetry breaking, period doubling, and intermittency crises are encountered.

A Therapeutic Approach of Chitosan-loaded p-Coumaric Acid Nanoparticles to Alleviate Diabetic Nephropathy in Wister Rats.

Objective: This study evaluated the renoprotective effects of p-Coumaric acid nanoparticles (PCNPs) in nephropathic rats.

Methods: Six groups of male Albino Wistar rats were randomly assigned. Group 1 was the control, while Group 2 received 45 mg/kg of streptozotocin (STZ) to induce diabetic nephropathy.

pmiRScan: a LightGBM based method for prediction of animal pre-miRNAs.

MicroRNAs (miRNA) are categorized as short endogenous non-coding RNAs, which have a significant role in post-transcriptional gene regulation. Identifying new animal precursor miRNA (pre-miRNA) and miRNA is crucial to understand the role of miRNAs in various biological processes including the development of diseases. The present study focuses on the development of a Light Gradient Boost (LGB) based method for the classification of animal pre-miRNAs using various sequence and secondary structural features.

Psychiatric manifestations of encephalitis.

Objective: Encephalitis is a serious and potentially life-threatening condition of infectious or autoimmune cause. We aim to characterize the frequency and clinical spectrum of presenting psychiatric symptoms in encephalitis in order to inform earlier recognition and initiation of treatment.

Methods: This was a retrospective study of adult patients who met the 2013 International Encephalitis Consortium (IEC) and/or 2016 Graus criteria between February 2005 and February 2023.

Trichuriasis in Human Patients from Côte d'Ivoire Caused by Novel Trichuris incognita Species with Low Sensitivity to Albendazole/Ivermectin Combination Treatment.

Albendazole/ivermectin combination therapy is a promising alternative to benzimidazole monotherapy alone for Trichuris trichiura control. We used fecal DNA metabarcoding to genetically characterize Trichuris spp. populations in patient samples from Côte d'Ivoire showing lower (egg reduction rate <70%) albendazole/ivermectin sensitivity than those from Laos and Tanzania (egg reduction rates >98%).

Human Papilloma Virus Circulating Cell-Free DNA Kinetics in Patients with Cervical Cancer Undergoing Definitive Chemoradiation.

Purpose: Human papillomavirus (HPV) is a significant cause of cervical cancer. We hypothesized that detecting viral cell-free HPV DNA (cfDNA) before, during, and after chemoradiation (chemoRT) could provide insights into disease extent, clinical staging, and treatment response.

Experimental Design: A total of 66 patients with locally advanced cervical cancer were enrolled between 2017 and 2023, with 49 receiving standard-of-care treatment and 17 participating in a clinical trial combining a therapeutic HPV vaccine (PDS0101; IMMUNOCERV).

EMBL's European Bioinformatics Institute (EMBL-EBI) in 2024.

The European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) is one of the world's leading sources of public biomolecular data. Based at the Wellcome Genome Campus in Hinxton, UK, EMBL-EBI is one of six sites of the European Molecular Biology Laboratory, Europe's only intergovernmental life sciences organization. This overview summarizes the latest developments in services that EMBL-EBI data resources provide to scientific communities globally (https://www.

Clinical Reasoning: A 63-Year-Old Man With Progressive Multicranial Neuropathy and Leptomeningeal Enhancement.

A 63-year-old man, with a history of melanoma and basal cell carcinoma, presented with progressive right-sided facial numbness, vertical diplopia, and headache. Brain MRI revealed leptomeningeal enhancement of multiple cranial nerves and an enhancing mass-like lesion along the anterolateral surface of the pons and midbrain. Subsequent brain biopsy demonstrated the final diagnosis.

Reservoir computing with logistic map.

Recent studies on reservoir computing essentially involve a high-dimensional dynamical system as the reservoir, which transforms and stores the input as a higher-dimensional state for temporal and nontemporal data processing. We demonstrate here a method to predict temporal and nontemporal tasks by constructing virtual nodes as constituting a reservoir in reservoir computing using a nonlinear map, namely, the logistic map, and a simple finite trigonometric series. We predict three nonlinear systems, namely, Lorenz, Rössler, and Hindmarsh-Rose, for temporal tasks and a seventh-order polynomial for nontemporal tasks with great accuracy.

Affective response to daily physical activity in younger and older adults.

Many older adults do not meet the physical activity recommendations of the American Heart Association; hence, it is important to understand the factors that can facilitate regular physical activity in older adults. Notably, the role of affective response has been understudied. Mixed findings have been reported in terms of age effects in affective response to daily physical activity.

Clinical and diagnostic features of central nervous system tuberculosis in Indian children - a descriptive study.

Background: Children with tuberculous meningitis (TBM) present with diagnostic challenges as they often have atypical clinical features.

Objective: To describe the baseline characteristic features of children diagnosed with central nervous system (CNS) TB (TBM and tuberculoma).

Design: Retrospective descriptive study.

High-Performance p-Type Quasi-Ohmic of WSe Transistors Using Vanadium-Doped WSe as Intermediate Layer Contact.

Two-dimensional (2D) transition-metal dichalcogenides (TMDCs), such as tungsten diselenide (WSe), hold immense potential for applications in electronic and optoelectronic devices. However, a significant Schottky barrier height (SBH) at the metal-semiconductor (MS) interface reduces the electronic device performance. Here, we present a unique 2D/2D contact method for minimizing contact resistance and reducing the SBH.

Machine learning approach to predict blood-secretory proteins and potential biomarkers for liver cancer using omics data.

Identifying non-invasive blood-based biomarkers is crucial for early detection and monitoring of liver cancer (LC), thereby improving patient outcomes. This study leveraged computational approaches to predict potential blood-based biomarkers for LC. Machine learning (ML) models were developed using selected features from blood-secretory proteins collected from the curated databases.