Publications by authors named "Venkataramasubramanian Vaithiyanathan"
Article Synopsis
- Researchers developed a method to create chiral β-fluoroamines from α-fluoro cyclic ketones and α-amidosulfones using a chiral catalyst and KF as the base, achieving high enantioselectivity even at elevated temperatures.
- The process is notable for being transition-metal-free, straightforward, and allowing the direct use of stable precursors, which simplifies the synthesis of sensitive imines.
- This method provides excellent stereoselectivity, yielding products with up to 99% enantiomeric excess and scalability for synthesizing biologically relevant compounds, including those with C-Cl and C-Br centers.
