Publications by authors named "Venkata Vamsee Aditya Mallajosyula"
In this work, we find that CD8 T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) are the human equivalent of Ly49CD8 regulatory T cells in mice and are increased in the blood and inflamed tissues of patients with a variety of autoimmune diseases. Moreover, these CD8 T cells efficiently eliminated pathogenic gliadin-specific CD4 T cells from the leukocytes of celiac disease patients in vitro. We also find elevated levels of KIRCD8 T cells, but not CD4 regulatory T cells, in COVID-19 patients, correlating with disease severity and vasculitis.
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- KIR CD8 T cells, a subset of immune cells, are found in increased numbers in blood and tissues of people with autoimmune diseases and infections like COVID-19 and influenza.
- These KIR CD8 T cells can effectively target and eliminate harmful CD4 T cells associated with conditions such as Celiac disease.
- The presence of these cells is linked to disease severity in COVID-19, suggesting they regulate other T cells to manage autoimmunity and infection.
Lyme disease is one of most common vector-borne diseases, reporting more than 300,000 cases annually in the United States. Treating Lyme disease during its initial stages with traditional tetracycline antibiotics is effective. However, 10-20% of patients treated with antibiotic therapy still shows prolonged symptoms of fatigue, musculoskeletal pain, and perceived cognitive impairment.
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