Publications by authors named "Venkata Surekha Mullapudi"
In India, total vitamin B12 (Vit B12) and its active form (active B12) have not been studied in mother's blood and cord blood. We hypothesized that total and active B12 levels are sufficiently maintained in cord blood despite low levels in mothers. Two hundred term pregnant mother's blood and cord blood was collected and analyzed for total Vit B12 (radioimmunoassay method) and active B12 levels (enzyme-linked immunosorbent assay).
View Article and Find Full Text PDF, and extracts and their effects on gut microbiota modulations (prebiotic potential), basal inflammatory markers and lipid levels: oral supplementation study in healthy rats.
Pharm Biol
December 2022
Context: Linn (Labiatae) (OS), Rose (Zingiberaceae) (ZO), and Linn (Piperaceae) (PN) are used in traditional medicine as immunomodulator, anti-inflammatory, and bioavailability enhancer agents.
Objective: Active phytoconstituents of OS, ZO, PN hydro-alcoholic extracts and their effects on gut microbiota, basal inflammation and lipid profile were investigated in rats.
Materials And Methods: Active phytoconstituents of extracts were analysed using HPLC and GC-MS.
Expression of iron transport protein Divalent metal transporter 1 (DMT1) increases in response to maternal iron deficiency anemia in near term to term placenta.
J Matern Fetal Neonatal Med
March 2022
Article Synopsis
- Iron deficiency anemia (IDA) is the most common nutritional deficiency in pregnant women and affects the expression of the iron transport protein DMT1 in the placenta.
- A study involving 200 pregnant women found that 58.8% had anemia, with higher DMT1 expression levels in the placentas of anemic mothers compared to nonanemic ones.
- The results indicate that severe maternal anemia leads to increased DMT1 expression, which helps regulate iron transport to the developing fetus.
During pregnancy, iron is transferred from mother to fetus with placental iron transport proteins (Transferrin receptor, Divalent metal transporter/DMT1, ferroportin/FPN1 and Zyklopen). The aim of the study was to evaluate the effect of maternal iron deficiency anemia on placental iron transporters. Two hundred pregnant women, in third trimester of pregnancy were divided into anemic (Hemoglobin/Hb < 11g/dl) and non-anemic groups (Hb ≥ 11 g/dl).
View Article and Find Full Text PDFBackground & Objectives: Stearoyl-CoA desaturase 1 (SCD1) is a key lipogenic enzyme responsible for endogenous synthesis of monounsaturated fatty acids (MUFA) and plays a key role in various pathophysiology, including fatty liver diseases. In this experimental study the impact of vitamin A deficiency was assessed on SCD1 regulation in relation to kidney biology, under high fructose (HFr) diet-fed condition in rats.
Methods: Forty male weanling (21 day old) Wistar rats were divided into four groups control, vitamin A-deficient (VAD), HFr, VAD with HFr consisting of eight rats each, except 16 for the VAD group.
Article Synopsis
- The study investigates how maternal anemia affects the expression of angiogenic proteins in the placenta, focusing on VEGF, PLGF, nitrotyrosine, and e-NOS.
- In total, 48 pregnant women were analyzed, categorized into normal, mild, moderate, and severe anemia groups, with 58.3% being anemic.
- Results indicated that anemic mothers showed higher levels of these proteins in their placentas, suggesting that this may be a compensatory mechanism to adapt to altered blood flow and oxygen delivery.
Purpose: Consumption of Western diet high in fat and fructose has been attributed to the recent epidemic of nonalcoholic fatty liver disease (NAFLD). However, the impact of specific fatty acids on the progression of NAFLD to nonalcoholic steatohepatitis (NASH) is poorly understood. In the present study, we investigated the chronic effects of consumption of fructose in combination with saturated fatty acids (SFA) or trans fatty acids (TFA) on the development of NAFLD.
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