Chitosan-Glycerol Gel as Barrier Formulation for Metal Allergy.

Metal-induced allergic contact dermatitis, particularly nickel, affects over 10% of the general population. Herein, chitosan-glycerol gel as protective barrier formulation was synthesized by neutralization reaction with an aim to reduce metal-ion diffusion into the skin to prevent allergy. Active functional groups in chitosan-glycerol gel were able to capture allergenic metal ions present in artificial sweat solution.