Publications by authors named "Venkata Siva Reddy Devireddy"
Drug resistant tuberculosis is a major public health concern, since the causative agent Mycobacterium tuberculosis is resistant to the most effective drugs against tuberculosis treatment ie., rifampicin and isoniazid. Globally, it accounts 4.
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- Favipiravir is typically taken orally, but this study explores its effectiveness when delivered directly to the lungs via inhalation to achieve higher concentrations at the site of infection and bypass liver metabolism.
- Researchers created a dry powder inhalation formulation and tested it on mice, comparing the inhaled doses to standard oral doses to measure drug concentration in the blood and lungs.
- Results showed that inhaling a much smaller dose of favipiravir (1/25th of the oral dose) resulted in higher drug levels in the lungs and similar effectiveness in the blood, supporting the potential for a targeted method of treating respiratory viral infections.