Selection and optimization of nano-formulation of P-glycoprotein inhibitor for reversal of doxorubicin resistance in COLO205 cells.

Objective: The prime objective of current work was to develop a strategy for preparation of combinational nano-formulation for reversal of drug resistance.

Methods: As a model system, doxorubicin (DOX)-resistant COLO205 cells were developed and validated. From co-treatment studies with DOX, curcumin was selected as it reversed DOX-resistance at lowest concentration.

Molecular target-guided tumor therapy with natural products derived from traditional Chinese medicine.

A tremendous interest exists in the Western world in Traditional Chinese Medicine (TCM) with rapidly increasing export rates of TCM products from China to Europe and USA. This led to a national decision of the Chinese government to implement a "Plan for the Modernization of Chinese Medicine". Concerning the use of Chinese medicinal herbs, two major directions can be distinguished.