In-silico driven design and development of spirobenzimidazo-quinazolines as potential DNA gyrase inhibitors.

DNA gyrase and Topoisomerase IV are promising antibacterial drug targets as they regulate bacterial DNA replication and topology. In a quest for novel DNA topoisomerase inhibitors, a multidisciplinary approach was adopted that involves computational prediction of binding sites and molecular modelling followed by green synthesis and biological evaluation of antibacterial activity of spirobenzimidazo quinazolines derivatives. Using basic quantum chemistry principles, we evaluated spirobenzimidazo quinazolines derivatives with their pharmacokinetic profiles.

The first total synthesis and biological evaluation of marine natural products ma'edamines A and B.

We have developed the first total syntheses of marine natural products ma'edamines A (18) and B (20). Structurally, they contain a pyrazine-2-(1H)-one core and were screened for antiproliferative activity on several cancer cell lines. Out of the six cell lines tested, ma'edamines A and B showed significant cytotoxicity against human colon cancer line COLO 205 (IC(50) 7.

Studies on exhaust emissions of catalytic coated spark ignition engine with adulterated gasoline.

Adulteration of automotive fuels, especially, gasoline with cheaper fuels is widespread throughout south Asia. Some adulterants decrease the performance and life of the engine and increase the emission of harmful pollutants causing environmental and health problems. The present investigation is carried out to study the exhaust emissions from a single cylinder spark ignition (SI) engine with kerosene blended gasoline with different versions of the engine, such as conventional engine and catalytic coated engine with different proportions of the kerosene ranging from 0% to 40% by volume in steps of 10% in the kerosene-gasoline blend.