Publications by authors named "Venkata Ramana Devi"
Inflammation is of critical importance in successful implantation during pregnancy. However, the establishment of maternal immune tolerance towards semi-allograft foetus is more exigent and is achieved predominantly by human leukocyte antigen-G (HLA-G) isoforms with a special emphasis on soluble HLA-G5 (sHLA-G5). Constant inflammation and lack of resolution by anti-inflammatory milieu, due to aberrant expression of critical immunoregulatory molecules such as sHLA-G5 and dysfunctional T helper cells 1 and 2 (Th1-Th2) cytokine shift, can lead to adverse pregnancy outcomes including recurrent pregnancy loss (RPL).
View Article and Find Full Text PDFArticle Synopsis
- Human growth hormone plays a significant role in the progression of breast cancer, affecting cellular proliferation and the epithelial-mesenchymal transition process.
- The study found that the production of human growth hormone leads to increased activation of nuclear factor-κB, which promotes cell growth and reduces apoptosis in breast cancer cells.
- Understanding the relationship between human growth hormone and nuclear factor-κB could help identify potential treatment options for breast cancer by targeting this signaling pathway.