Publications by authors named "Venkata N Kamineni"

Evidence of microplastics (MPs) and nanoplastics (NPs) in foods and daily-use products, along with their frequent detection in the human body, has raised concerns regarding their potential impact on human health through dietary ingestion. However, there is a lack of quantitative tools to simulate their bioaccumulation and tissue distribution following environmental exposure. To address this gap, we developed the first physiologically based toxicokinetic (PBTK) model for predicting the biodistribution of MPs and NPs in mice following oral exposure under various exposure scenarios.

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Article Synopsis
  • Plasma half-life is important for estimating withdrawal periods of drugs in food animals to ensure food safety.
  • This study created a QSAR model using machine learning algorithms to predict plasma half-lives for drugs in cattle, chickens, goats, sheep, swine, and turkeys, utilizing data from FARAD.
  • The deep neural network (DNN) algorithm showed the best prediction performance, achieving strong accuracy and leading to the development of a user-friendly web dashboard for broader scientific use.
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Nanoparticles (NPs) can be designed for targeted delivery in cancer nanomedicine, but the challenge is a low delivery efficiency (DE) to the tumor site. Understanding the impact of NPs' physicochemical properties on target tissue distribution and tumor DE can help improve the design of nanomedicines. Multiple machine learning and artificial intelligence models, including linear regression, support vector machine, random forest, gradient boosting, and deep neural networks (DNN), were trained and validated to predict tissue distribution and tumor delivery based on NPs' physicochemical properties and tumor therapeutic strategies with the dataset from Nano-Tumor Database.

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