Mechanisms of Hypoxia in COVID-19 Patients: A Pathophysiologic Reflection.

Coronavirus disease-2019 (COVID-19) causes severe hypoxemia which fulfills the criteria of acute respiratory distress syndrome (ARDS) but is not accompanied by typical features of the syndrome. The combination of factors including low P/F ratios, high A-a gradient, relatively preserved lung mechanics, and normal pulmonary pressures may imply a process occurring on the vascular side of the alveolar-capillary unit. The scant but rapidly evolving data available on the pathophysiology are seemingly conflicting, indicating the relative dominance of intrapulmonary shunting or dead space in different studies.

Epidemiological and Clinical Characteristics of COVID-19 in Indian Children in the Initial Phase of the Pandemic.

Objective: To assess the epidemiological and clinical characteristics of pediatric inpatients with COVID-19, early in the pandemic.

Methods: Clinical and laboratory profile and outcomes were studied for children (aged 1 month - 18 years) presenting between 1 April, 2020 and 20 May, 2020 with positive nasopharyngeal swab for SARS-CoV-2 by RT-PCR.

Results: 50 children (56% male) with median (IQR) age of 6 (2-12) years were included.

Growth Parameters of under 2-year-old Indian Children: A Comparison to WHO MGRS 2006 Charts.

Context: Growth is an important biological process by which an individual reaches a point of complete physical development. Growth monitoring of a child is a very important utility to detect the deviation from normal growth. In India, for children below 2 years of age WHO multicentre growth reference study (MGRS) 2006 charts are being used for growth monitoring, which were prepared by measuring children from six different countries who were raised in optimum conditions of health and nutrition.

Estimation of prostaglandin E2 levels in gingival crevicular fluid in periodontal health, disease and after treatment.

Background And Objectives: Initial research has shown a positive correlation between the severity of periodontal disease (PD) and prostaglandin E2 (PGE2) concentrations in gingival crevicular fluid (GCF). However, there are no enough reports to correlate the PGE2 concentrations in GCF in periodontal health, disease and after treatment. Hence, the present study is aimed to estimate the levels of PGE2 in GCF in periodontal health, disease and after periodontal therapy.