Publications by authors named "Venkat Gundabala"

Article Synopsis
  • A new microfluidic technique has been developed to create stable water-in-water emulsions without stabilizers, overcoming challenges with size and stability control.
  • The technique utilizes an acoustically actuated mixer to rapidly homogenize solutions like PEG and Dextran, resulting in uniformly distributed emulsions stabilized in alginate gels.
  • The emulsions show high mixing efficiency and biocompatibility, making them suitable for applications in drug delivery, cosmetics, and food.
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With a goal to finding suitable alternatives to plastic packaging in the food industry, we developed a multifunctional bio-based active packaging film to enhance the shelf life of red meat. A chitosan/alginate (Chi + Alg) bilayer film was developed through layer-by-layer (LBL) assembly and an active material i.e.

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Waterborne coatings with intrinsic antibacterial attributes have attracted significant attention due to their potential in mitigating microbial contamination while simultaneously addressing the environmental drawbacks of their solvent-based counterparts. Typically, antimicrobial coatings are designed to resist and eliminate microbial threats, encompassing challenges such as biofilm formation, fungal contamination, and proliferation of black mold. Iodine, when solubilized using ethylene glycol and incorporated as a complex into waterborne latex dispersions, has shown remarkable antimicrobial activity.

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Development of spatially organized structures and understanding their role in controlling kinetics of multistep chemical reactions are essential for the successful design of efficient systems and devices. While studies that showcase different types of methodologies for the spatial organization of various colloidal systems are known, design and development of well-defined hierarchical assemblies of liquid-crystal (LC) droplets and subsequent demonstration of biological reactions using such assemblies still remain elusive. Here, we show reversible and reconfigurable one-dimensional (1D) assemblies of protein-bioconjugate-sequestered monodisperse LC droplets by combining microfluidics with noninvasive acoustic wave trapping technology.

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The rapid increase in multidrug resistant biofilm infections is a major concern for global health. A highly effective therapy is required for the treatment of biofilm related infections. In this study, curcumin loaded alginate microfibers were generated by using the microfluidic technique.

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Microfluidics based techniques for generation of cell-laden microbeads are emerging as an attractive route to 3D cell encapsulation due to the precise control provided by microfluidics. However, existing microfluidics based cell encapsulation methods are restricted to 2D planar devices and use of passive methods for droplet generation. In this work, we report the development of a 3D glass-PDMS (polydimethylsiloxane) hybrid device for complete on-chip generation of cell-laden alginate beads in the presence of electric fields.

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In this work, we present a microfluidics-based microfiber fabrication method with the ability to control both the fiber size and the extent of coiling of the generated fiber. This latter feature allows on-demand generation of both nonwoven and single fiber within the same device, broadening the scope of application of the fabricated fibers. Using a hybrid poly(dimethylsiloxane) (PDMS)-glass microfluidic device, we implement a coflowing solvent removal technique to generate poly(ethylene oxide) (PEO) fibers.

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In this work, we present a robust microfluidic platform for controlled and complete on-chip generation of alginate microcapsules with single and double liquid cores. A combined Coflow and T-junction configuration implemented in a hybrid glass-PDMS (Polydimethylsiloxane) device is used for the generation of microcapsules with oil as liquid core. Frequency matching of oil-alginate double emulsion generation with that of aqueous Calcium chloride droplet generation allows for controlled merging of the two, resulting in reliable production of microcapsules.

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