Publications by authors named "Venkanna Gujja"
The main objective of this study is to produce novel triazoles-loaded tetrazoles, which are crucial in the development of prospective therapeutic agents in medicinal chemistry. Recent investigations have found a wide range of uses for these derivatives, and they are prospective lead molecules for the synthesis of substances with enormous therapeutic utility for various diseases, especially for bacterial therapy. New series of 1,2,3-triazole derivatives have been synthesized from methyl (2S,4S)-4-azido-1-(2,4-difluoro-3-methylbenzoyl)pyrrolidine-2-carboxylate () using a well-established click reaction that has several advantages to afford a novel heterocyclic compound based on tetrazole moieties.
View Article and Find Full Text PDFBackground: A novel series of 1,3,4‒oxadiazole connected to derivatives of quinazolinone (7a-e and 8a-f) was synthesized in the current investigation, and its anticancer and Topoisomerase‒ II inhibitory activity was evaluated.
Objective: These findings inspired the design, synthesis, and biological analysis of these 1,3,4‒oxadiazole-quinazolinone analogues as antiproliferative Topo‒II inhibitors.
Methods: The novel compound structures were determined using mass spectrometry and spectral methods (IR, NMR: H & C).
Article Synopsis
- Researchers found that 1,2,3-triazole and tetrazole derivatives with pyrrolidines are effective in medicinal chemistry and could help in discovering new drugs.
- A new group of compounds that include indazole and 1,2,3-triazolyltetrazoles showed strong antibacterial and antifungal activity, with some compounds performing similarly to the standard antifungal drug, Itraconazole.
- The binding interactions of these compounds within a target protein in S. aureus and their promising molecular properties indicate that they could lead to the development of new antimicrobial agents through further modifications.