Publications by authors named "Vendula Kralova"
Article Synopsis
- Human 17β-hydroxysteroid dehydrogenase type 10 is a key mitochondrial enzyme linked to neurological diseases like Parkinson's and Alzheimer's through its interaction with amyloid-beta.
- Researchers developed around 60 new compounds derived from a benzothiazolyl scaffold to test their ability to inhibit this enzyme.
- The most effective inhibitors, with specific chemical modifications, demonstrated low IC values and an uncompetitive inhibition mechanism, suggesting they could be potential drug candidates for neurodegenerative disorders.
