Effect of suppression of otoacoustic emissions in individuals with and without central auditory processing disorder: a systematic review.

Objective: To investigate, through a systematic review of the literature, whether there are differences in the results of otoacoustic emissions suppression tests in individuals with and without central auditory processing disorder.

Methods: Searches were carried out in the scientific databases Latin American and Caribbean Health Sciences Literature, PubMed, Scientific Electronic Library Online, Web of Science, Scopus, Science Direct and Cochrane, as well as the databases of gray literature British Library, OpenGrey.eu and Object View and Interaction Design.

Prostaglandin E/Leukotriene B balance and viral load in distinct clinical stages of COVID-19: A cross-sectional study.

Background: Prostaglandin E (PGE) and leukotriene B (LTB) are eicosanoids involved in modulation of the antiviral immune response. Recent studies have identified increased levels of several eicosanoids in the plasma and bronchoalveolar lavage of patients with coronavirus disease (COVID-19). This study investigated correlations between plasma levels of PGE and LTB and clinical severity of COVID-19.

Does a patient with acquired arbovirus infection have a hearing impairment? A scoping review of hearing changes in an adult with Dengue, Chikungunya, and Zika.

Objectives: To identify and understand the evidence regarding hearing changes related to acquired Dengue, Chikungunya, and Zika virus infection in adult individuals.

Methods: A scoping review was performed according to the recommendations of The Joanna Briggs Institute and guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews in the Embase, PubMed/Medline, ScienceDirect, Scopus, and Web of Science databases without restriction on language and year of publication. Case studies, observational studies, and clinical trials reporting hearing loss in adult subjects (>18-60 years of age) of both sexes with DENV, CHIKV, or ZIKV diagnosed by positive molecular/serological examination by RT-PCR or IgM/IgG by ELISA method were included.

Cochlear radiation dose and hearing loss in patients with vestibular schwannoma undergoing radiosurgery: systematic review.

Objectives: To determine the cut-off point of the cochlear radiation dose as a risk factor for hearing loss in patients with vestibular schwannoma treated with radiosurgery.

Methods: A systematic review of the literature was performed without language or publication year restrictions in the MEDLINE/PubMed, EMBASE, Web of Science, LILACS/VHL and Cochrane Library databases. Studies that met the following criteria were included: 1) population: adults of both sexes who underwent radiosurgery for vestibular schwannoma treatment; 2) exposure: cochlear radiation; 3) outcome: hearing loss; 4) type of study: cohort.

Effects of climate variability on respiratory diseases in the Western Region of Bahia, Brazil.

Objectives: This study aimed to analyse hospitalisations for respiratory diseases in the Western Region of Bahia, Northeast Brazil, from 2010 to 2019, and to explore possible correlations with meteorological data.

Study Design: This descriptive, epidemiological, ecological study analysed data from 37 municipalities in the Western Bahia health macro-region, defined according to geographical, administrative, demographic, epidemiological, social and cultural criteria, and accounting for availability of health resources.

Methods: Hospitalisation data for respiratory diseases, including total admissions and disease frequency, mean and prevalence, were obtained from DATASUS (Ministry of Health).

Effect of phthalocyanine oral and nasal antiseptic solutions on the infectivity of SARS-CoV-2 in patients with COVID-19: a randomized controlled trial.

Background: In individuals with coronavirus disease (COVID-19), the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load (VL) plays an important role in infectivity.

Objectives: This study aimed to evaluate the reduction in the VL and infectivity induced by phthalocyanine mouthwash and nasal spray in patients with COVID-19.

Methods: Patients with mild COVID-19 were recruited to participate in a triple-blinded randomized controlled trial.

Coagulopathy and the humoral response against viral proteins in patients at different stages of COVID-19.

Background: Patients with severe coronavirus disease 2019 (COVID-19) often present with coagulopathies and have high titres of circulating antibodies against viral proteins.

Objectives: Herein, we evaluated the association between D-dimer and circulating immunoglobulin levels against viral proteins in patients at different clinical stages of COVID-19.

Methods: For this, we performed a cross-sectional study involving patients of the first wave of COVID-19 clinically classified as oligosymptomatic (n = 22), severe (n = 30), cured (n = 27) and non-infected (n = 9).

Cortical Auditory Evoked Potentials in Children with Prenatal Exposure to Zika Virus.

Prenatal exposure to ZIKV can cause neurologic and auditory damage. The electrophysiological responses obtained by Cortical Auditory Evoked Potentials (CAEP) may provide an objective method to investigate the function of cortical auditory pathways in children exposed to ZIKV. This case series analyzed the findings of CAEP in prenatal-period ZIKV-exposed children with and without microcephaly.

Frequency-Following Response and Auditory Behavior in Children with Prenatal Exposure to the Zika Virus.

 Prenatal exposure to the Zika virus can impair neurodevelopment and cause auditory damage.  To analyze the frequency-following response (FFR) and the auditory behavior (with the questionnaire) of children with and without prenatal exposure to Zika virus infection.  A total of 30 children participated in the present study, divided into 3 groups: 10 children with microcephaly and prenatal exposure to the Zika virus; 10 normocephalic children with prenatal exposure to the Zika virus; and 10 children with no evidence of prenatal exposure to the virus.

Impact of drought associated with high temperatures on Coffea canephora plantations: a case study in Espírito Santo State, Brazil.

Droughts are major natural disasters that affect many parts of the world all years and recently affected one of the major conilon coffee-producing regions of the world in state of Espírito Santo, which caused a huge crisis in the sector. Therefore, the objective of this study was to conduct an analysis with technical-scientific basis of the real impact of drought associated with high temperatures and irradiances on the conilon coffee (Coffea canephora Pierre ex Froehner) plantations located in the north, northwest, and northeast regions of the state of Espírito Santo, Brazil. Data from 2010 to 2016 of rainfall, air temperature, production, yield, planted area and surface remote sensing were obtained from different sources, statistically analyzed, and correlated.

Mapping within‑field variability of soybean evapotranspiration and crop coefficient using the Earth Engine Evaporation Flux (EEFlux) application.

Accurate information about the spatiotemporal variability of actual crop evapotranspiration (ETa), crop coefficient (Kc) and water productivity (WP) is crucial for water efficient management in the agriculture. The Earth Engine Evapotranspiration Flux (EEFlux) application has become a popular approach for providing spatiotemporal information on ETa and Kc worldwide. The aim of this study was to quantify the variability of water consumption (ETa) and the Kc for an irrigated commercial planting of soybeans based on the EEFlux application in the western region of the state of Bahia, Brazil.

Atypical β-S haplotypes: classification and genetic modulation in patients with sickle cell anemia.

β-S globin haplotype (β haplotype) characterization in sickle cell anemia (SCA) patients is important because it assists individualized treatment. However, the patient with atypical haplotypes do not present detailed studies such as clinical and laboratory data. To understand the phenotypic expression of atypical haplotype patients in relation to typical haplotype ones, it may be necessary to assess the main clinical and laboratorial parameters and investigate transcription factors, as possible genetic modulators that can contribute to the improvement of the SCA patients' clinical condition.

Analysing sulphate and chloride in mineral drinking water by flow injection analysis with a single acoustic wave sensor.

Sulphate is a very hydrophilic anion, and, therefore, difficult to be selectively determined in aqueous solution with a coated sensor. Zinc(II) 2,3,9,10,16,17,23,24-Octatosylaminophthalocyanine was used for the first time as a sensitive coating. Selectivity to sulphate regarding chloride was not enough to ignore its contribution in mineral waters, and, therefore, an analytical protocol was carefully designed to allow the determination of both anions with this sensor.

Mutational Profile of Homozygous β-Thalassemia in Rio de Janeiro, Brazil.

β-Thalassemia (β-thal) is a hemolytic anemia that is caused by point mutations in most cases. The Brazilian population is highly heterogeneous and knowledge of the mutations that make up the genotypic profile of individuals can contribute information about the formation of the population and clinical condition of patients. In this study, we evaluated the mutations present in homozygous β-thal patients from Rio de Janeiro, Brazil.

Thesis Abstract Morphological and phylogeographic analysis of Brazilian tortoises (Testudinidae).

The discriminative potentials of biogeography, vocalization, morphology, cytogenetics, hemoglobin, and molecular profiling of cytochrome b as taxonomic techniques for differentiating Brazilian tortoises were evaluated in this study. In Brazil, two species of tortoises are described, Chelonoidis carbonarius and Chelonoidis denticulatus. However, in the present study, some animals that were initially recognized based on morphological characters and coloring did not correspond to the typical pattern of C.

Screening of Transcription Factors Involved in Fetal Hemoglobin Regulation Using Phylogenetic Footprinting.

Fetal hemoglobin (Hb F) is an important genetic modulator of the beta-hemoglobinopathies. The regulation of Hb F levels is influenced by transcription factors. We used phylogenetic footprinting to screen transcription factors that have binding sites in HBG1 and HBG2 genes' noncoding regions in order to know the genetic determinants of the Hb F expression.

Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer.

Functional polymorphisms in promoter regions can produce changes in the affinity of transcription factors, thus altering the messenger ribonucleic acid (mRNA) expression levels of inflammatory cytokines associated with the risk of cancer development. The goal of this study was to evaluate the influence that polymorphisms in the cytokine genes known as TNF-α-308 G/A (rs1800629), TNF-α-857 C/T (rs1799724), IL-8-251 T/A (rs4073), IL-8-845 T/C (rs2227532), and IL-10-592 C/A (rs1800872) have on changes to mRNA expression levels and on the risks of chronic gastritis (CG) and gastric cancer (GC). A sample of 723 individuals was genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.

Performances of volume phase holographic grating for space applications: study of the radiation effect.

The special properties of volume phase holographic gratings make them promising candidates for spectrometry applications where high spectral resolution, low levels of straylight, and low polarization sensitivity are required. Therefore it is of interest to assess the maturity and suitability of volume phase holographic gratings as enabling technologies for future space missions, with demanding requirements for spectrometry. One of the main areas of research is related to grating ageing under space radiation.

Geoffroy's side-necked turtle [Phrynops geoffroanus (Schweigger, 1812), Testudines: Chelidae] as a model for evolutionary ecotoxicology: relationship between environmental contamination, conditions and genetic variability.

The objective of this study was to evaluate the role of human activity factors, such as environmental contamination and habitat changes, as drivers for changing the physiological, biochemical, and genetic diversity of Geoffroy's side-necked turtle populations in one of the most impacted watersheds in southeastern Brazil. The impact of chemical and organic contamination was determined by ecotoxicological analyses to assess the action of some of the major components involved in protection against oxidative stress, phase I and II detoxification metabolism, and antioxidant capacity. The results indicated the influence of domestic and industrial effluents on detoxification metabolism and oxidative stress.