Durable remission of locally advanced breast cancer with multimodality management.

We treated 20 women with locally advanced breast cancer between January 1991 and September 1996. The treatment regimen included 4 cycles of intensive doxorubicin (30 mg/m2/d on 3 consecutive days every 2 weeks with G-CSF support), followed by appropriate surgery, followed by high dose therapy with cyclophosphamide, carboplatin and thiotepa (STAMP V, CTCb). Of the 20 patients, seven presented with inflammatory breast cancer, three with Stage IIIB, seven with stage IIIA, one with multifocal Stage IIB and two with Stage IV M1 (ipsilateral supraclavicular lymph node involvement) (including one who had an inflammatory primary) disease.

Acidic isoferritin inhibitory activity: a normal granulopoietic regulator within long term mouse bone marrow cultures.

Long term murine bone marrow cultures maintain orderly granulopoiesis for several months. Assay of cell free supernatant obtained at weekly feedings from control cultures demonstrated endogeneously produced acidic isoferritin inhibitory activity. Addition of 10(9) M acidic isoferritin inhibitory activity to long term cultures gave a trend toward fewer nonadherent cells and fewer colony forming units-granulocyte/macrophage (CFU-GM) per flask, but this was not statistically significant.