Publications by authors named "Velda Teh"

Article Synopsis
  • Aberrant post-transcriptional regulation, particularly through RNA-binding proteins (RBPs) like LARP1, plays a significant role in cancer development, specifically colorectal cancer (CRC).
  • LARP1 is shown to be upregulated in CRC and interacts with the 3'UTR of the proto-oncogene MYC, enhancing its expression and promoting tumor growth.
  • This study highlights a feedback loop where MYC also regulates LARP1 expression, creating a cycle that contributes to CRC tumorigenesis.
View Article and Find Full Text PDF

3'UTR shortening in cancer has been shown to activate oncogenes, partly through the loss of microRNA-mediated repression. This suggests that many reported microRNA-oncogene target interactions may not be present in cancer cells. One of the most well-studied oncogenes is the transcription factor MYC, which is overexpressed in more than half of all cancers.

View Article and Find Full Text PDF
Article Synopsis
  • Half of all miRNA are found in intronic regions and often transcribed with their host genes, yet most studies overlook their collective impact on cancer progression.
  • The research focused on intronic miRNA in colon cancer, showing that a long noncoding RNA and several intronic miRNA work together to promote cancer growth by interacting with proteins that regulate gene expression.
  • Findings revealed that specific intronic miRNA can inhibit tumor suppressors and enhance cancer signaling pathways, highlighting the complex interactions within multigenic loci and their significance in cancer progression.
View Article and Find Full Text PDF