Publications by authors named "Veit Bertram"
Article Synopsis
- TRPS1 is a nuclear protein found in breast epithelial cells and has potential as a breast cancer marker, based on a study analyzing 19,201 samples from various tumor types.
- In breast carcinomas, low TRPS1 expression correlates with aggressive features like high grade and nodal metastasis, but does not predict patient survival.
- The combination of TRPS1 and GATA3 immunostaining enhances cancer identification, particularly for breast and salivary gland tumors, while TRPS1 negativity helps differentiate urothelial carcinoma from breast cancer.
Context.—: Steroidogenic acute regulatory (StAR) protein is a mitochondrial transport protein with a critical regulatory role for steroid hormone production. The tissue distribution of StAR expression is limited to few human normal tissues.
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- * Analysis revealed PSAP expression was primarily confined to prostate tissues, with minimal detection in non-prostate cancers, indicating its specificity for prostate cancer diagnosis.
- * Reduced levels of PSAP are linked to more aggressive cancer features, making it a potential candidate for inclusion in prognostic assessments for ERG-negative prostate cancer patients.