The motor-learning process of older adults in eccentric bicycle ergometer training.

This study describes the motor-learning process of older individuals during the course of a training intervention on a motor-driven eccentric bicycle ergometer. Seventeen women and 16 men (64 ± 6 yr) took part in a 10-wk training program. Uniformity of force production and consistency of timing were used to describe their motor performance.

Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice.

Background: Diabetes has negative, and exercise training positive, effects on the skeletal muscle vasculature, but the mechanisms are not yet fully understood. In the present experiment the effects of running exercise on the mRNA expression of pro- and antiangiogenic factors were studied in healthy and diabetic skeletal muscle. The responses in capillaries and muscle fibers, collected from the muscle with laser capture microdissection, were also studied separately.

Effects of acute exercise, exercise training, and diabetes on the expression of lymphangiogenic growth factors and lymphatic vessels in skeletal muscle.

Blood and lymphatic vessels together form the circulatory system, allowing the passage of fluids and molecules within the body. Recently we showed that lymphatic capillaries are also found in the capillary bed of skeletal muscle. Exercise is known to induce angiogenesis in skeletal muscle, but it is not known whether exercise has effects on lymphangiogenesis or lymphangiogenic growth factors.

A single bout of exercise with high mechanical loading induces the expression of Cyr61/CCN1 and CTGF/CCN2 in human skeletal muscle.

High mechanical loading was hypothesized to induce the expression of angiogenic and/or lymphangiogenic extracellular matrix (ECM) proteins in skeletal muscle. Eight men performed a strenuous exercise protocol, which consisted of 100 unilateral maximal drop jumps followed by submaximal jumping until exhaustion. Muscle biopsies were taken 30 min and 48 h postexercise from the vastus lateralis muscle and analyzed for the following parameters: mRNA and protein expression of ECM-associated CCN proteins [cysteine-rich angiogenic protein 61 (Cyr61)/CCN1, connective tissue growth factor (CTGF)/CCN2], and mRNA expression of vascular endothelial growth factors (VEGFs) and hypoxia-inducible factor-1alpha.

Localisation of lymphatic vessels and vascular endothelial growth factors-C and -D in human and mouse skeletal muscle with immunohistochemistry.

The present study was aimed to localise lymphatic vessels and their growth factors in human and mouse skeletal muscle with immunohistochemistry and specific antibodies (VEGFR-3, LYVE-1, VEGF-C and VEGF-D). The largest lymphatic vessels were found in perimysial connective tissue next to the arteries and veins, as has been shown earlier with electron microscopy. As a new finding, we also found small LYVE-1 positive vessels in the capillary bed between muscle fibres.

Effects of experimental type 1 diabetes and exercise training on angiogenic gene expression and capillarization in skeletal muscle.

Diabetes alters microvascular structure and function and is a major risk factor for cardiovascular diseases. In diabetic skeletal muscle, impaired angiogenesis and reduced VEGF-A expression have been observed, whereas in healthy muscle exercise is known to have opposite effects. We studied the effects of type 1 diabetes and combined exercise training on angiogenic mRNA expression and capillarization in mouse skeletal muscle.

The effects of a four-day march on the gonadotrophins and mood states of army officers.

The effects of daily repeated prolonged exercise on gonadotrophin levels and mood states were studied in six physically active army officers participating in a 4-day march totaling 185 km. We hypothesized that submaximal daily repeated prolonged exercise may disturb the balance of the hypothalamic-pituitary-testicular axis, which could be determined from the concentrations of serum luteinizing hormone and follicle-stimulating hormone with time-resolved immunofluorometric assay. In addition, the mood states of the men were followed during the exercise period.

Physical activity and breast cancer risk among female physical education and language teachers: a 34-year follow-up.

The cohort consisted of 1,489 Finnish female physical education and 8,560 language teachers born after 1920 and alive in 1967. The 2 study populations were similar in social class and way of living and clearly discordant in physical activity both during their university studies and later in life. The incidence of breast cancer among these teachers up to the year 2000 was assessed through a record linkage with the Finnish Cancer Registry.

Hormonal responses to daily strenuous walking during 4 successive days.

The hormonal response to 4 days' walking exercise (totaling 164 km) was examined among 15 healthy males. We hypothesised that submaximal daily, repeated, prolonged exercise may disturb the balance of the adrenal cortex and pituitary-testicular axis, which could be analysed from the concentrations of serum cortisol and testosterone, and with time-resolved immunofluorometric assay (IFMA) of luteinising hormone (LH) and follicle stimulating hormone (FSH). In the adrenal cortex the increased response to acute exercise could be seen after the 1st day.

Isometric cervical extension force and dimensions of semispinalis capitis muscle.

The anatomy of the human cervical region has a special complexity. Ultrasonography is a scanning technique, which has been successfully used to identify and measure the cervical muscle dimensions. The purpose of this study was to detect with the use of real-time ultrasonography the dimensional changes of the human semispinalis capitis muscle (SECM) during isometric cervical extension.

Self-experienced physical workload and risk of breast cancer.

Objectives: The association between the risk of breast cancer and the physical load of work was studied because physical activity may reduce breast cancer risk via hormonal mechanisms.

Methods: Occupational physical activity was estimated from a self-determined rating [scale 1 (low)-5 (high)] of occupational physical load for 1800 randomly selected women born in 1930-1969. The medians of the ratings were used as occupation-specific indices of occupational physical activity.