Publications by authors named "Vegesna Naga Sravan Kumar Varma"
Iran J Pharm Res
September 2016
Article Synopsis
- The research focused on creating a pH-sensitive co-polymer, specifically poly acrylamide-grafted-guar gum (PAAm-g-GG), through a chemical modification process known as free radical polymerization.
- Esomeprazole magnesium (ESO) was used to formulate intestinal-targeted nanoparticles (NPs) using this co-polymer, involving a nano-emulsification polymer crosslinking method which resulted in nanoparticles of varying sizes (200-600 nm).
- The study found that drug release from the nanoparticles was significantly influenced by the surrounding pH, showing delayed release in acidic conditions while allowing gradual release in alkaline conditions, with the nanoparticles displaying uniform size and smooth surface characteristics.
