Publications by Veerle Pertz

Publications by authors named "Veerle Pertz"

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Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia.

Pavinder Kaur Niklas Feldhahn Bin Zhang Daniel Trageser Markus Müschen Veerle Pertz

Mol Cancer

October 2007

Background: Ph-positive leukemias are caused by the aberrant fusion of the BCR and ABL genes. Nilotinib is a selective Bcr/Abl tyrosine kinase inhibitor related to imatinib, which is widely used to treat chronic myelogenous leukemia. Because Ph-positive acute lymphoblastic leukemia only responds transiently to imatinib therapy, we have used mouse models to test the efficacy of nilotinib against lymphoblastic leukemia caused by the P190 form of Bcr/Abl.

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