Identifying patients with chronic lymphocytic leukemia without need of treatment: End of endless watch and wait?

Introduction: Early-stage chronic lymphocytic leukemia (CLL) challenges specialized management and follow-up.

Methods: We developed and validated a prognostic index to identify newly diagnosed patients without need of treatment (CLL-WONT) by a training/validation approach using data on 4708 patients. Composite scores derived from weighted hazards by multivariable analysis defined CLL-WONT risk groups.