Multiple logistic regression analysis predicts cancer risk among tobacco usage with glutathione -transferase p1 genotyping in patients with head and neck cancer.

Introduction: Numerous studies have been investigated to understand the association between glutathione S-transferase P1 (GSTP1) polymorphism and risk of head and neck cancer (HNC) but yielded contradictory results, and no studies could confirm polymorphism in GSTP1 and that tobacco usage increases the risk of HNCs. Therefore, this study aimed to understand the association of GSTP1 Ile105Val polymorphism with or without tobacco usage in carcinogenesis and clinicopathological characteristics of patients with HNC.

Materials And Methods: Binary logistic regression analysis was performed to predict HNC risk with tobacco use and GSTP1 genotyping.