Renal Protective Effects of Combination of Diltiazem and ACEI/ARB on the Progression of Diabetic Nephropathy: Randomized Controlled Trial.

Background: Strict control of blood sugar and maintenance of normal blood pressure levels are the standard treatments shown to delay the progression of diabetic nephropathy in type 2 diabetic patients. The recommended antihypertensive medications for diabetic nephropathy are angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB). Previous studies have shown that a non-dihydropyridine calcium channel blocker (diltiazem) could reduce urinary protein excretion in type 2 diabetic patients.

Somatic HRPT2 Mutation (Arg234X) of Parathyroid Carcinoma Associated with Slipped Capital Femoral Epiphysis: A First Case Report.

A 14-year-old boy was admitted to the orthopedic clinic of Rajavithi Hospital complaining of pain in the left hip. A year earlier, pain had developed in his left joint and had gradually increased in intensity in both hips. A month before he was referred, radiographs obtained at another hospital showed bilateral slipped capital femoral epiphysis (SCFE).

Prevalence of Diabetic Foot Ulcers and Risk Classifications in Type 2 Diabetes Mellitus Patients at Rajavithi Hospital.

Background: Diabetic foot ulcers are a major cause of non-traumatic lower limb amputation in patients with type 2 diabetes. In 2014, the Diabetes Association of Thailand issued new guidelines for classifying type 2 diabetes patients' levels of risk of developing foot ulcers, but no research on the prevalence of type 2 diabetes using these new classification criteria had been performed prior to the current study.

Objective: To study the prevalence of diabetic foot ulcers overall and in different risk groups in type 2 diabetes mellitus patients in Rajavithi Hospital, and to evaluate risk factors of these groups and correlations with ankle brachial index (ABI) and cardio-ankle vascular index (CAVI).

A prospective, longitudinal, multicenter, observational study to assess insulin treatment patterns in diabetic patients in Thailand: results from the TITAN Study.

Objective: To assess usage patterns, effectiveness, andsafety of newly prescribed insulin treatment in patients with diabetes in Thailand

Material And Method: Type 1 or type 2 diabetes mellitus patients who failed achievement of HbA1c <7%, and were about to start or switch to a new insulin treatment were enrolled into this prospective, longitudinal, multicenter observational study. Data regarding insulin usage pattern, HbA1c, fasting plasma glucose (FPG), and hypoglycemia were collected at enrollment, three and six-month.

Results: Between July 2008 and February 2010, 751 patients were recruited Mean (SD) age was 57.

A case of anterior mediastinum paraganglioma presented with pericardial effusion two years before symptoms of catecholamine excess: first case report in Thailand.

Pheochromocytoma (PCC) and paraganglioma (PGL) are uncommon tumors. Clinical manifestations are mass effect or hormone secretion. The initial manifestation with pericardial effusion is rare.

Fulminant type I diabetes: the first case report in Thailand.

Type 1 diabetes is classified as either autoimmune (type IA) or idiopathic (type IB) diabetes. Fulminant type 1 diabetes is a recently-discovered subtype of idiopathic type 1 diabetes. It is defined as diabetes with complete abrupt onset of beta cell destruction and progression to hyperglycemia and ketoacidosis within a short period of time, but with a near-normal HbA1c level.

Novel COL1A1 gene mutation (R1026X) of type I osteogenesis imperfecta: A first case report.

A 22-year-old Thai man with blue sclera, normal height and absence of deformity sustained an open fracture at the right talus and talo-navicular dislocation while playing in a volleyball match. The patient had a history of several fractures of his elbows, wrists and ankles from minor impacts. Novel COL1A1 nonsense mutation (c.

Maternal 25 hydroxyvitamin D level and its correlation in Thai gestational diabetes patients.

Objective: To identify 25 hydroxyvitamin D (250HD) levels in Thai pregnant women with gestational diabetes and nongestational diabetes.

Material And Method: This prospective study was conducted on 197 pregnant women at Rajavithi Hospital, a tertiary care medical center in Bangkok from October 2010 to July 2011. Plasma 25 hydroxyvitamin D concentration and HbA1c level during the 75 g OGTT in gestational diabetes mellitus (GDM) and non-GDM were evaluated.

Association between hs-CRP and Hba1c in overweight type 2 diabetic female patients.

Background And Objective: High-sensitive C-reactive protein (hs-CRP) is associated with atherosclerosis. Previous studies have shown that hs-CRP is associated with insulin resistance, type 2 diabetes and higher HbA1c levels. As type 2 diabetes is often found in overweight women, the present study investigated the relationship between hs-CRP and HbA1c levels in such patients.

Sensitivity of HRPT2 mutation screening to detect parathyroid carcinoma and atypical parathyroid adenoma of Thai patients.

Objective: Detected HRPT2 mutation in parathyroid carcinoma or atypical parathyroid adenoma in sporadic hyperparathyroidism in Thai patients.

Material And Method: Samples of parathyroid carcinoma, typical (atypical) adenoma or hyperplasia were obtained for HRPT2 gene (17 exons) study since September 2001 to August 2010 both somatic and germline by SyBr Green PCR method.

Results: Parathyroid carcinomas and atypical parathyroid adenoma from 5 of 26 patients (10 of 32 samples) were tested for HRPT2 mutations.

Abnormal liver function test in Graves' disease: a prospective study of comparison between the hyperthyroid state and the euthyroid state.

Background: Abnormal liver function test is sometimes seen in hyperthyroidism but no study had been carried out to compare liver function test in the hyperthyroid state and the euthyroid state.

Objective: This study aimed to find the prevalence of abnormal liver function test in Graves' disease and compare liver function test result in the hyperthyroid state with the euthyroid state.

Material And Method: This is a prospective study of 112 patients who had Graves' disease.

Role of loading calcitriol to control hypocalcemia after parathyroidectomy in chronic kidney disease.

Objective: To compare the effective calcitriol regimens in hypocalcimic hyperparathyroidism (HPT) patients who were referred to parathyroidectomy.

Material And Method: Retrospective study of fifty patients who underwent parathyroidectomy in Rajavithi Hospital between September 2001 and August 2009 was performed. The authors defined three regimens of calcitriol (A; fixed dose regimen, B; titrated dose regimen and C; loading dose regimen) by reviewing 41 charts of patients with chronic kidney disease.

Proptosis in normal Thai samples and thyroid patients.

Objective: Find normal values of proptosis in Thai population and study proptosis in Graves' disease and Hashimoto's thyroiditis.

Material And Method: Measurement of proptosis was made with Luedde exophthalmometer by one examiner in 277 normal Thai subjects and 591 thyroid patients.

Results: The mean proptosis of 168 normal Thai female patients was 11.