Publications by authors named "Veeraf Sanjana"
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
Science
December 2010
Article Synopsis
- Researchers conducted a genome-wide association study focusing on HIV-1 controllers and progressors to understand genetic factors influencing chronic viral infections.
- They discovered over 300 significant single-nucleotide polymorphisms (SNPs) specifically within the major histocompatibility complex (MHC), emphasizing its importance for infectious diseases.
- Key findings indicate that specific amino acids in HLA proteins, especially HLA-B and HLA-C, significantly influence the interaction between HLA and viral peptides, affecting the control of HIV infection.
Immune Reconstitution Inflammatory Syndrome (IRIS) is an inflammatory syndrome in the context of immune restoration directed at a specific infectious antigen despite resolution of infection, often associated with opportunistic infections. IRIS has been reported in 30% to 35% of HIV patients who have cryptococcosis in whom antiretroviral therapy was initiated. We would like to report a case of IRIS localized to the eye secondary to cryptococcal infection.
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