Publications by authors named "Veera Luukkonen"
Article Synopsis
- Obesity is linked to inflammation in adipose tissue (AT) and the secretion of extracellular vesicles (EVs), which play a role in metabolic disorders; however, the exact mechanisms are not fully understood.
- Research examined EVs from human adipocytes and AT in subjects undergoing bariatric surgery, using various advanced analytical techniques to understand the characteristics and behaviors of these EVs in response to different treatments.
- Findings indicated that mature adipocytes release more EVs than preadipocytes, with inflammatory stimuli further enhancing EV secretion, particularly from visceral AT; this suggests a connection between increased EV release, AT expansion, and inflammation in obesity.
Cells respond to invading pathogens and danger signals from the environment by adapting gene expression to meet the need for protective effector molecules. While this innate immune response is required for the cell and the organism to recover, excess immune activation may lead to loss of homeostasis, thereby promoting chronic inflammation and cancer progression. The molecular basis of innate immune defence is comprised of factors promoting survival and proliferation, such as cytokines, antimicrobial peptides and anti-apoptotic proteins.
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