First-Line Combination with Proteasome Inhibitor-Based Treatment and Zoledronic Acid Is Effective in Reducing Later Fractures in Multiple Myeloma Irrespective of Multiple Myeloma Bone Disease at Diagnosis.

The present study provides real-world evidence on the treatment of multiple myeloma (MM) bone disease with various bisphosphonates combined for different myeloma-specific treatments as no validated data regarding the best combination treatment for bone disease associated with MM are available. We examined retrospectively 345 MM patients treated with autologous stem cell transplantation in Finland during 1996-2020. The median age of the patients was 60 years with a median follow-up time of 50 months (1-339).

nCPAP treatment of obstructive sleep apnea increases slow wave sleep in prefrontal EEG.

According to standard sleep stage scoring, sleep EEG is studied from the central area of parietal lobes. However, slow wave sleep (SWS) has been found to be more powerful in frontal areas in healthy subjects. Obstructive sleep apnea syndrome (OSAS) patients often suffer from functional disturbances in prefrontal lobes.

Apnea patients show a frontopolar inter-hemispheric spindle frequency difference.

Sleep apnea syndrome is known to disturb sleep. The purpose of the present work was to study spindle frequency in apnea patients. All-night sleep EEG recordings of 15 apnea patients and 15 control subjects with median ages of 47 and 46 years, respectively, were studied.