Systematic evaluation of machine learning models for postoperative surgical site infection prediction.

Background: Surgical site infections (SSIs) lead to increased mortality and morbidity, as well as increased healthcare costs. Multiple models for the prediction of this serious surgical complication have been developed, with an increasing use of machine learning (ML) tools.

Objective: The aim of this systematic review was to assess the performance as well as the methodological quality of validated ML models for the prediction of SSIs.

First records of penicillate millipedes (Diplopoda, Polyxenidae) from Thailand, with descriptions of two new species.

Two new species are described from the family Polyxenidae. Monographis panhai sp. nov.

Assessing the Relative Importance of Satellite-Detected Methane Superemitters in Quantifying Total Emissions for Oil and Gas Production Areas in Algeria.

Methane emissions from oil and gas production provide an important contribution to global warming. We investigate 2020 emissions from the largest gas field in Algeria, Hassi R'Mel, and the oil-production-dominated area Hassi Messaoud. We use methane data from the high-resolution (20 m) Sentinel-2 instruments to identify and estimate emission time series for 11 superemitters (including 10 unlit flares).

Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation.

Nephronophthisis (NPH), an autosomal recessive ciliopathy, results from mutations in more than 20 different genes (NPHPs). These gene products form protein complexes that regulate trafficking within the cilium, a microtubular structure that plays a crucial role in developmental processes. Several NPHPs, including NPHP2/Inversin, have been linked to extraciliary functions.

Four new species of Monographis Attems, 1907 (Diplopoda, Polyxenida, Polyxenidae) from Vietnam.

Four new species of penicillate millipedes from the genus Monographis Attems, 1907, collected from various regions in Vietnam, are described. They show distinctive morphological characteristics on the labrum, telotarsus, and sensilla on antennal article VI. Monographis cattienensis sp.

CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice.

Aims/hypothesis: Accumulating evidence suggests that leucocytes play a critical role in diabetes-induced vascular lesions and other abnormalities that characterise the early stages of diabetic retinopathy. However, the role of monocytes has yet to be fully investigated; therefore, we used Ccr2 mice to study the role of CCR2 inflammatory monocytes in the pathogenesis of diabetes-induced degeneration of retinal capillaries.

Methods: Experimental diabetes was induced in wild-type and Ccr2 mice using streptozotocin.

Intersystem Crossing Rates in Photoexcited Rose Bengal: Solvation versus Isolation.

We compare the intersystem crossing rate, , of Rose Bengal (RB) in an aqueous pH 12 solution with the corresponding relaxation rates of four different RB-derived anion and dianion species isolated in the gas phase: the doubly deprotonated dianion ([RB-2H]), the singly deprotonated monoanion ([RB-H]), and the corresponding singly negatively charged sodium and cesium adducts ([RB-2H + Na] and [RB-2H + Cs], respectively). Each of them was probed following photoexcitation of their first singlet excited states (S) at or near room temperature. The solution was studied by transient absorption spectroscopy, whereas the mass-selected anions were characterized by time-resolved photoelectron spectroscopy─all with ca.

Clock genes rescue nphp mutations in zebrafish.

The zebrafish pronephros model, using morpholino oligonucleotides (MO) to deplete target genes, has been extensively used to characterize human ciliopathy phenotypes. Recently, discrepancies between MO and genetically defined mutants have questioned this approach. We analyzed zebrafish with mutations in the nphp1-4-8 module to determine the validity of MO-based results.

Gunshot trauma in human long bones: towards practical diagnostic guidance for forensic anthropologists.

In contrast to cranial gunshot trauma, diagnosis and interpretation of gunshot trauma to long bones remains difficult and controversial. The aim of this study is to review the published literature on fracture patterns resulting from gunshot trauma in human long bones, and to use the described characteristics to provide practical guidance for the forensic anthropologist. In order to achieve this, medical and forensic publications on this topic were reviewed.

Three new species of penicillate millipedes from the Con Dao Islands of southeast Vietnam (Diplopoda, Lophoproctidae and Polyxenidae).

We describe three new penicillate millipede species from Con Dao Archipelago in southeastern Vietnam: Alloproctoides consonensis n. sp. (Lophoproctidae), Monographis condorensis n.

Transcriptomic Analysis of a Susceptible African Maize Line to Infection.

Maize ( L.) is a staple crop providing food security to millions of people in sub Saharan Africa. , an important fungal pathogen, infects maize causing ' Ear Rot' disease, which decreases maize kernel yield and the quality of the crop harvested.

Six common behavioral trials and their relevance for perch performance in natural lakes.

Behavioral traits measured in laboratory settings are commonly used when predicting ecological effects and evolutionary outcomes in natural systems. However, uncertainties regarding the relevance of simplified lab-based behavioral tests for complex natural environments have created doubts about the use of these tests within aquatic ecology and ecotoxicology. In this study, we scrutinize the assumption that fish performance in six commonly applied behavioral assays has relevance for in situ behavior, by comparing individual behavior tracked in both artificial laboratory settings as well as in two natural lakes.

Ultrafast Intersystem Crossing in Isolated Ag(BDT) Probed by Time-Resolved Pump-Probe Photoelectron Spectroscopy.

The photophysics of the isolated trianion Ag(BDT) (BDT = benzenedithiolate), a ligand-protected cluster comprising BDT-based ligands, terminating a shell of silver thiolates and a core of silver atoms, was studied in the gas phase by femtosecond time-resolved, pump-probe photoelectron spectroscopy. UV excitation at 490 nm populates one or more singlet excited states with significant charge transfer (CT) character in which electron density is shifted from shell to core. These CT states relax on an average time scale of several hundred femtoseconds by charge recombination to yield either the vibrationally excited singlet ground state (internal conversion) or a long-lived triplet (intersystem crossing).

Establishing phone-pair co-usage by comparing mobility patterns.

In forensic investigations it is often of value to establish whether two phones were used by the same person during a given time period. We present a method that uses time and location of cell tower registrations of mobile phones to assess the strength of evidence that any pair of phones were used by the same person. The method is transparent as it uses logistic regression to discriminate between the hypotheses of same and different user, and a standard kernel density estimation to quantify the weight of evidence in terms of a likelihood ratio.

Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy.

Purpose: Recent evidence suggests that retinal photoreceptor cells have an important role in the pathogenesis of retinal microvascular lesions in diabetes. We investigated the role of rod cell phototransduction on the pathogenesis of early diabetic retinopathy (DR) using Gnat1-/- mice (which causes permanent inhibition of phototransduction in rod cells without degeneration).

Methods: Retinal thickness, oxidative stress, expression of inflammatory proteins, electroretinograms (ERG) and optokinetic responses, and capillary permeability and degeneration were evaluated at up to 8 months of diabetes.

Two new species (Diplopoda, Polyxenida, Lophoproctidae) from Queensland, Australia.

Verhoeff, 1924 was the first penicillate millipede in the family Lophoproctidae collected from Cairns, a tropical region in Queensland, Australia, to be formally described. Specimens collected from this region in a recent study had the morphological characters known to define this genus. However, their body form and length, as well as dorsal colouration proved to be different, suggesting the possibility of more than one species.

Two new species of penicillate millipedes (Diplopoda, Polyxenidae) from Phu Quoc Island in southern Vietnam.

Two new penicillate millipede species from the genera Unixenus and Monographis (Diplopoda, Polyxenidae) were collected from Phu Quoc Island, Vietnam's largest island. Unixenus intragramineus sp. n.

Resisting attraction: Individual differences in executive control are associated with subject-verb agreement errors in production.

We propose that attraction errors in agreement production (e.g., the key to the cabinets are missing) are related to two components of executive control: working memory and inhibitory control.

Photobiomodulation Inhibits Long-term Structural and Functional Lesions of Diabetic Retinopathy.

Previous studies demonstrated that brief (3 to 4 min) daily application of light at 670 nm to diabetic rodents inhibited molecular and pathophysiologic processes implicated in the pathogenesis of diabetic retinopathy (DR) and reversed diabetic macular edema in small numbers of patients studied. Whether or not this therapy would inhibit the neural and vascular lesions that characterize the early stages of the retinopathy was unknown. We administered photobiomodulation (PBM) therapy daily for 8 months to streptozotocin-diabetic mice and assessed effects of PBM on visual function, retinal capillary permeability, and capillary degeneration using published methods.

A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration.

Degeneration of retinal photoreceptor cells can arise from environmental and/or genetic causes. Since photoreceptor cells, the retinal pigment epithelium (RPE), neurons, and glial cells of the retina are intimately associated, all cell types eventually are affected by retinal degenerative diseases. Such diseases often originate either in rod and/or cone photoreceptor cells or the RPE.

Tracing the policy implementation of commitments made by national governments and other entities at the Third Global Forum on Human Resources for Health.

We conducted a follow-up analysis of the implementation of the Human Resources for Health (HRH) commitments made by country governments and other actors at the Third Global Forum on HRH in 2013. Since then member states of the WHO endorsed Universal Health Coverage as the main policy objective whereby health systems strengthening, including reinforcement of the health workforce, can contribute to several Sustainable Development Goals. Now is the right time to trace the implementation of these commitments and to assess their contribution to broader global health objectives.

Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes.

Purpose: Loss of photoreceptor cells is associated with retinal vascular degeneration in retinitis pigmentosa, whereas the presence of photoreceptor cells is implicated in vascular degeneration in diabetic retinopathy. To investigate how both the absence and presence of photoreceptors could damage the retinal vasculature, we compared two mouse models of photoreceptor degeneration (opsin-/- and RhoP23H/P23H ) and control C57Bl/5J mice, each with and without diabetes.

Methods: Retinal thickness, superoxide, expression of inflammatory proteins, ERG and optokinetic responses, leukocyte cytotoxicity, and capillary degeneration were evaluated at 1 to 10 months of age using published methods.

How (Not) to Talk on Twitter: Effects of Politicians' Tweets on Perceptions of the Twitter Environment.

Politicians' Twitter habits can vary considerably. Those who choose to use may do so as part of a broad discussion community or as a one-to-many broadcaster. Because each user sees a different mix of tweets, a politician seen by one user as interacting with the public may be seen by another as engaging in one-way communication, potentially prompting different evaluations of the politician, the ongoing discussion, or even Twitter itself.

The impact of bilingualism on working memory in pediatric epilepsy.

Impairments in executive skills broadly span across multiple childhood epilepsy syndromes and can adversely affect quality of life. Bilingualism has been previously shown to correlate with enhanced executive functioning in healthy individuals. This study sought to determine whether the bilingual advantage in executive functioning exists in the context of pediatric epilepsy.