Publications by authors named "Veena Lanka"
Arimoclomol: a potential therapy under development for ALS.
Expert Opin Investig Drugs
December 2009
Article Synopsis
- Arimoclomol is being studied as a potential treatment for amyotrophic lateral sclerosis (ALS) due to its ability to enhance heat shock protein expression, which helps cells respond to stress.
- Research indicates that arimoclomol can improve survival and muscle function in mouse models of ALS, and initial human safety studies support its use at doses up to 300 mg/day.
- Ongoing studies are exploring its effects in patients with familial ALS linked to specific genetic mutations, highlighting its promise as a therapeutic option for both sporadic and familial forms of the disease.
Several therapies have shown promise in preclinical models of motor neuron disease. Several of these treatment approaches, however, failed in human studies. In moving forward with new promising therapies, it is important to first identify whether the past trials were unsuccessful due to wrong therapy and biological target or because of flaws in trial design and conduct.
View Article and Find Full Text PDF