Neuronal loss after transsection of the facial nerve: a morphological and neurophysiological study in monkeys.

Functional recovery after nerve lesions seems to depend on peripheral as well as central factors. To investigate the central neuronal loss after transsection of a pure motor nerve, the middle branch of the facial nerve on one side was transsected and immediately repaired microsurgically by epineural suturing. After a period of 6-15 months, a quantitative neurophysiological recording was made to estimate muscle response.

Pharyngeal flaps after one- and two-stage repair of the cleft palate: a 25-year review of 520 patients.

Between 1962 and 1976, a one-stage surgical procedure was performed on 328 cases of cleft lip and palate or isolated cleft palate. From 1977 to 1986, a two-stage surgical procedure was performed on 192 patients. After one-stage repair, 22 (6.

Fibrin glue: its use for skin grafting of contaminated burn wounds in areas difficult to immobilize.

A human fibrin glue was used in patients with burns for fixation of skin grafts on slightly infected wounds in the axillas, perineum, and the gluteal folds. These areas had been left open after previous skin transplantations. There was stable and safe adhesion and little inflammatory reaction between the graft and the recipient area, resulting in favorable conditions for graft incorporation.

Argon laser treatment of port-wine stains: the patients' evaluations of the result.

The argon laser is now a well-established method of treating port-wine stains (PWS) in the face and neck areas. Satisfactory results are reported in 44 to 75 percent of cases, but criteria for that classification and the patients' perceptions of the result are seldom given. In the present paper, a sample of 58 patients was used to assess the patients' own perceptions of the degree of lightening and scarring.

Experimental dynamic cardiomyoplasty in sheep.

To evaluate electrically stimulated muscle grafts for augmenting ventricular function in cardiac insufficiency, dynamic cardiomyoplasty was performed in nine sheep, using latissimus dorsi (LD) muscle wrapped as a pedicle around the left ventricle. Beginning 2 weeks postoperatively, LD was stimulated synchronously with the heart. After 6 and 12 weeks of stimulation, hemodynamic evaluation was done and biopsies were taken for histochemical and biochemical analysis.

Osteocutaneous grafting from the forearm to the foot. Case report.

A vascularised osteocutaneous flap from the forearm was transferred to a crushed forefoot after a motorbike accident. Rapid bone formation and good coverage of the wound led to normal walking within nine months. This method can overcome the difficult problem of metatarsal bone and soft tissue loss and confers considerable benefit on the patient.

Angiographic findings and need for amputation in high tension electrical injuries.

Because it is difficult to estimate the extent of deep tissue injury clinically, angiography was carried out in 28 patients with signs of damage from current flow through the body. Eight of the arteriograms showed normal extremities, 6 showed changes of small arteries, and 38 showed injury to the main arteries. In the latter group there were 24 total arterial occlusions, narrow irregular lumens in 10, and 4 had occlusion and distal refilling.

Cross-face nerve grafting followed by free muscle transplantation in young patients with long-standing facial paralysis. Reanimation of the cheek and the angle of the mouth.

For reanimation of the cheek in 8 young patients with long-standing facial palsy a method with cross-face nerve grafting followed by free muscle transplantation has been used. The sural nerve was used as nerve graft and placed in a subcutaneous tunnel across the face. In the normal cheek 3-4 fascicles of the nerve were anastomosed to facial nerve branches innervating muscles elevating the angle of the mouth.

Formation of neuromuscular junctions in transplanted peroneus longus muscles in the rat. A quantitative comparison with reinnervation of the muscle in situ.

The formation of neuromuscular junctions in free heterotopic muscle transplants in the rat has been studied quantitatively and compared with the reinnervation of the muscle in situ. The AChE-containing area and the nerve terminal were stained in the same longitudinal section and the length of end-plate, the average number of nerve terminal branch points within the end-plate and the terminal innervation ratio (TIR) were determined. In denervated muscles we noticed early disappearance of nerves whereas the AChE-stained end-plates were visible after eight weeks.

Freely transplanted peroneus longus muscle in the cat reinnervated by a single nerve: physiological properties.

Physiological properties (tetanic tension, single twitch, fatigability) of free autologous muscle transplants in cats were examined in vivo five months after transplantation. After 2 weeks denervation the peroneus longus muscle was placed isometrically in the abdomen with the omentum around the muscle and with the proximal end of a cut branch of the femoral nerve attached to the muscle. (In one case a sensory nerve was used.

Light- and electron microscopic findings in the distal end of human cross-face sural nerve grafts.

In five patients with long-standing facial palsy we have tried to improve the possibility of elevating the angle of the mouth by bringing regenerating axons from the facial nerve on the normal side through a sural nerve graft to a transplanted free muscle in the paralyzed cheek. In order to expect clinical improvement a sufficient number of axons must grow into and through the sural nerve graft, neuromuscular contacts must be formed, and the transplanted muscle must be vascularized and survive. In order to find out if axons had regenerated, light- and electronmicroscopic examinations of a biopsy from the tip of the sural nerve graft were carried out at the time of muscle transplantation.

Reconstructing the antihelix of protruding ears by perichondrioplasty: a modified technique.

Using the experiences achieved by experimental studies on cauliflower ear, protruding ears have been operated on with a technique involving the neochondrogenic potential of the perichondrium. The underdeveloped or absent conchoscaphal angle is restored to a normal antihelix in a posterior approach by a perichondrioplasty, gently folding the cartilage. The mobilized perichondrium is used to generate new cartilage, molding the folded cartilage in the desired position.

Hyaluronic acid stimulates neutrophil function in vitro and in vivo. A review of experimental results and a presentation of a preliminary clinical trial.

Hyaluronic acid (HA) stimulates normal neutrophil function both in vitro and in vivo Stimulation was also achieved by subcutaneous administration of HA to patients with extreme susceptibility to bacterial infections. Clinical improvement of some patients was obtained in connection to the administration. It is premature at this time to conclude any therapeutic effect of HA in patients with extreme infection propensity.