Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K[BOFOH] inhibits emerging multidrug-resistant and β-lactamase-producing opportunistic pathogens.

Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate, K[BOFOH] (boroxine) was previously shown to be very effective in inhibition of several carcinoma cell lines, including the skin cancer. Here, we investigated its antimicrobial potential by targeting the multidrug-resistant opportunistic pathogens associated with skin and wound infections. The antimicrobial testing against eleven bacterial and four fungal species revealed good activity of boroxine against pathogenic filamentous fungi and (MIC 64 and 128 µg/ml), and a moderate bioactivity against the yeast (MIC 512 µg/ml).