Association of Proteasome Activity and Pool Heterogeneity with Markers Determining the Molecular Subtypes of Breast Cancer.

Background: Proteasomes degrade intracellular proteins. Different proteasome forms were identified. Proteasome inhibitors are used in cancer therapy, and novel drugs directed to specific proteasome forms are developed.

Multikinase inhibitors modulate non-constitutive proteasome expression in colorectal cancer cells.

Proteasomes are multi-subunit protein complexes responsible for protein degradation in cells. Immunoproteasomes and intermediate proteasomes (together non-constitutive proteasomes) are specific forms of proteasomes frequently associated with immune response, antigen presentation, inflammation and stress. Expression of non-constitutive proteasome subunits has a prognostic value in several types of cancer.

Nucleoside Analog 2',3'-Isopropylidene-5-Iodouridine as Novel Efficient Inhibitor of HIV-1.

Nucleoside reverse transcriptase inhibitors are the first class of drugs to be approved by the FDA for the suppression of HIV-1 and are widely used for this purpose in combination with drugs of other classes. Despite the progress in HIV-1 treatment, there is still the need to develop novel efficient antivirals. Here the efficiency of HIV-1 inhibition by a set of original 5-substituted uridine nucleosides was studied.

Emetine in Combination with Chloroquine Induces Oncolytic Potential of HIV-1-Based Lentiviral Particles.

Chloroquine and Emetine are drugs used to treat human parasitic infections. In addition, it has been shown that these drugs have an antiviral effect. Both drugs were also found to cause a suppressive effect on the growth of cancer cells of different origins.

[Comparative estimation of diagnostic tests for helicobacter pylori and the spectrum of gastric mucosal microflora in gastritis and ulcer disease].

We estimated specificity and sensitivity of diagnostic tests for H. pylori (HP) infection in patients with gastroduodenal problems and studied species composition of gastric mucosal microflora in gastritis and ulcer disease. The following characteristics have been determined as the most informative signs of HP infection: HP fecal antigen, plasma total antibodies (IgG, IgA, IgM) against CagA, histological (cytological) findings confirming the presence of HP antigens in biopsies, rapid urease test, the presence of bent rods morphologically resembling HP in gastric mucosa biopsies cultured in the glycol medium for sterility control.