Publications by authors named "Vedant Sandhu"
Unlabelled: In many cancers, mortality is associated with the emergence of relapse with multidrug resistance (MDR). Thus far, the investigation of cancer relapse mechanisms has largely focused on acquired genetic mutations. Using acute myeloid leukemia (AML) patient-derived xenografts (PDX), we systematically elucidated a basis of MDR and identified drug sensitivity in relapsed AML.
View Article and Find Full Text PDFAcute myeloid leukemia (AML) is clinically and genetically a heterogeneous disease characterized by clonal expansion of abnormal hematopoietic progenitors. Genomic approaches to precision medicine have been implemented to direct targeted therapy for subgroups of AML patients, for instance, IDH inhibitors for mutated patients, and FLT3 inhibitors with mutated patients. While next generation sequencing for genetic mutations has improved treatment outcomes, only a fraction of AML patients benefit due to the low prevalence of actionable targets.
View Article and Find Full Text PDFArticle Synopsis
- * IDentif.AI was utilized to identify and design new drug combinations from 6 antibiotics, which showed higher effectiveness in inhibiting NTM compared to current treatment regimens.
- * Notable combinations like Levofloxacin/Rifabutin and Levofloxacin/Meropenem were found to have strong synergistic effects, suggesting that these could be the foundation for developing improved multi-drug therapies for NTM infections.