Publications by authors named "Ved P Mooga"
Background: Colorectal adenocarcinomas are characterized by abnormal mitochondrial DNA (mtDNA) copy number and genomic instability, but a molecular interaction between mitochondrial and nuclear genome remains unknown. Here we report the discovery of increased copies of nuclear mtDNA (NUMT) in colorectal adenocarcinomas, which supports link between mtDNA and genomic instability in the nucleus. We name this phenomenon of nuclear occurrence of mitochondrial component as numtogenesis.
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- The intermembrane space of mitochondria contains small chaperones called small TIMs, crucial for sorting hydrophobic precursors, characterized by a unique CX(3)C motif and stabilized by disulfide bonds.
- The study demonstrates that specific cysteine residues in small TIMs are not essential for the functions of Tim9 or Tim10 in yeast, indicating potential redundancy in their roles.
- Defective assembly of small TIMs leads to their breakdown through the mitochondrial protease Yme1, suggesting a quality control mechanism for maintaining mitochondrial protein integrity.
The biogenesis of mitochondria requires the import of a large number of proteins from the cytosol [1, 2]. Although numerous studies have defined the proteinaceous machineries that mediate mitochondrial protein sorting, little is known about the role of lipids in mitochondrial protein import. Cardiolipin, the signature phospholipid of the mitochondrial inner membrane [3-5], affects the stability of many inner-membrane protein complexes [6-12].
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