[Vaccination against diphtheria and tetanus of children with thymus hyperplasia syndrome].

Inhibition of cellular and humoral immunity was established in children with grade I thymus enlargement syndrome (TES). The most pronounced changes were recorded in children aged 1-5 years. Vaccination against diphtheria and tetanus performed before the diagnosis of the TES was made were followed by satisfactory output of anatoxins, indicating the prospectiveness of the vaccination of the given children's group with DPT vaccine and DT- and DT-M-anatoxin.

[Advantages of using pharmacologic tests to characterize bacterial vaccines].

The possibility of using pharmacological tests to determine side effects produced by adsorbed DPT vaccine and chemical typhoid vaccine was studied. Both vaccines were shown to be capable of prolonging sleep induced by hexenal or thiopental in experimental animals. The following difference in the action of these two preparations was revealed on the model of "chemical convulsions" induced by the injection of thiosemicarbazide: while immunization with DPT vaccine acitivated thiosemicarbazide-induced convulsive syndrome in mice, no such stimulating effect was observed after the injection of typhoid, vaccine.