Publications by authors named "Vaya Chen"
Article Synopsis
- Previous research indicated a connection between altered cerebral blood flow (CBF) after severe traumatic brain injury (sTBI) and poor executive function, but the effects on endothelial cells (ECs) and their cilia were not understood.
- A mouse model of sTBI was used to study changes in CBF, gene expression, and ciliary function in brain ECs through techniques like single cell RNA sequencing.
- Findings revealed sustained drops in CBF, alterations in EC sub-clusters, early activation of ischemic pathways, and a significant loss of ciliary gene expression and the cilia protein ARL13B in ECs within the first day post-injury, which continued throughout the injury period.
Visceral white adipose tissues (WAT) regulate systemic lipid metabolism and inflammation. Dysfunctional WAT drive chronic inflammation and facilitate atherosclerosis. Adipose tissue-associated macrophages (ATM) are the predominant immune cells in WAT, but their heterogeneity and phenotypes are poorly defined during atherogenesis.
View Article and Find Full Text PDFUnlabelled: Macrophage efferocytosis, the process by which phagocytes engulf and remove apoptotic cells (ACs), plays a critical role in maintaining tissue homeostasis. Efficient efferocytosis prevents secondary necrosis, mitigates chronic inflammation, and impedes atherosclerosis progression. However, the regulatory mechanisms of efferocytosis under atherogenic conditions remain poorly understood.
View Article and Find Full Text PDFObjective: There is an unmet clinical need for alternatives to autologous vessel grafts. Small-diameter (<6 mm) synthetic vascular grafts are not suitable because of unacceptable patency rates. This mainly occurs due to the lack of an endothelial cell (EC) monolayer to prevent platelet activation, thrombosis, and intimal hyperplasia.
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