How the immune mousetrap works: Structural evidence for the immunomodulatory action of a peptide from influenza NS1 protein.

One of the critical stages of the T-cell immune response is the dimerization of the intramembrane domains of T-cell receptors (TCR). Structural similarities between the immunosuppressive domains of viral proteins and the transmembrane domains of TCR have led several authors to hypothesize the mechanism of immune response suppression by highly pathogenic viruses: viral proteins embed themselves in the membrane and act on the intramembrane domain of the TCRalpha subunit, hindering its functional oligomerization. It has also been suggested that this mechanism is used by influenza A virus in NS1-mediated immunosuppression.

[About the first Soviet therapeutic elite: Lazar Borisovitch Buhshtab, the follower of V. P. Obraztsov, and his clinical school (Odessa)].

The first Soviet therapeutic elite took shape in the second half of the 1920s. This process was not limited by few capital cities. So, L.