IMPLEMENTATION OF THE EDUCATIONAL MODULE «MANAGING EXPOSURE ASSESSMENT AND MEDICAL RESPONSE TO A RADIATION EMERGENCY IN UKRAINE».

The WHO educational module УДК «Ma naging exposure assessment and medical response to a radiation emergency in Ukraine» was developed and implemented. In total, 25 trainings were conducted for 377 healthcare professionals from 6 regions of Ukraine during 2023-2024.

METHODOLOGY OF RECONSTRUCTION OF INTERNAL DOSES FROM 137Cs AND 134Cs OF RESIDENTS OF RADIOACTIVELY CONTAMINATED SETTLEMENTS IN UKRAINE NOT COVERED BY WBC MONITORING.

Objective: Scientific justification of the methodology for calculating radiation internal doses from 137Cs and 134Cs intake for residents of Ukrainian settlements radioactively contaminated as a result of the Chornobyl (Chernobyl) accident in which measurements of incorporated radiocesium isotopes in humans using whole-body counters (WBC) were not carried out.

Materials And Methods: The paper presents a new methodology for reconstructing doses due to internal irradiation from Chornobyl fallout for both surface (in 1986) and root (in 1987-2023) contamination of vegetation with 137Cs and 134Cs and their transfer into the human body. The methodology for calculating the dose due to surface contamination of vegetation was based on the theoretical model of the transfer of radiocesium isotopes through the food chain with further adjustment of this model to the results of WBC measurements carried out between 15 July and 31 December 1986.

STUDY OF DOSE FORMATION FOR THE POPULATION IN RADIOACTIVELY CONTAMINATED AREAS OF ZHYTOMYR REGION BASED ON COMPREHENSIVE RADIATION-HYGIENIC MONITORING.

Objective: the research is to determine the main radiation-hygienic factors influencing the formation of radiation doses among the population of radioactively contaminated territories (RCT) in Zhytomyr region in 2024 and to analyze the dynamics of internal radiation doses based on original experimental studies conducted in reference settlements from 2012 to 2024.

Materials And Methods: In 2024, a comprehensive radiation-hygienic monitoring program was conducted in 11 settlements of Narodychi Territorial Community (TC): the Narodychi and the villages of Selets, Bazar, Rudnya Bazarska, Khrystynivka (Zone 2), Motiyki, Zalissya, Davydky, Radcha, Nova Radcha, and Grezlya (Zone 3). The comprehensive radiation-hygienic monitoring included the following activities: mobile WBC monitoring: 817 measurements (562 adults and 255 children); collection and analysis of food samples: 39 milk samples, 61 potato samples, and 57 samples of wild foods, analyzed for radionuclide content, including 137Cs and 90Sr; assessment of external radiation exposure in these settlements; surveys: 194 individuals were surveyed regarding the consumption volumes of locally produced foods from their own households and purchased foods from commercial networks.

Metal-based nanoparticles: an alternative treatment for biofilm infection in hard-to-heal wounds.

Metal-based nanoparticles (MNPs) are promoted as effective compounds in the treatment of bacterial infections and as possible alternatives to antibiotics. These MNPs are known to affect a broad spectrum of microorganisms using a multitude of strategies, including the induction of reactive oxygen species and interaction with the inner structures of the bacterial cells. The aim of this review was to summarise the latest studies about the effect of metal-based nanoparticles on pathogenic bacterial biofilm formed in wounds, using the examples of Gram-positive bacterium and Gram-negative bacterium , as well as provide an overview of possible clinical applications.

ON THE METHODOLOGY OF PASSPORT DOSES CALCULATION FOR UKRAINIAN SETTLEMENTS RADIOACTIVELY CONTAMINATED DUE TO THE CHORNOBYL NPP ACCIDENT.

Objective: scientific substantiation of the new methodology for estimation of passport doses of the settlementswhich belong to Zone of Unconditional (obligatory) Resettlement, or 2nd zone and Zone of Granted VoluntaryResettlement, or 3rd zone in the framework of dosimetric passportization in accordance with the legislation ofUkraine.

Materials And Methods: 37 years after the accident, radioactive contamination of the environment has significantly decreased. However, it is still necessary to carry out ecological and dosimetric monitoring and apply countermeasures in certain territories of Ukraine affected by the accident at the Chornobyl Nuclear Power Plant: restriction of the consumption of locally produced milk, forest products, etc.

RETINA VESSELS CHANGES IN CHORNOBYL NUCLEAR POWER PLANT EMPLOYEES WHO EXPERIENCED LONG-TERM ABNORMAL RADIATION EXPOSURE AT THE WORKPLACE AS A RESULT OF THE OCCUPATION OF CHORNOBYL NUCLEAR POWER PLANT IN 2022.

Unlabelled: During the occupation of the Chornobyl Nuclear Power Plant (ChNPP) in 2022, a group of employees remained in the working town for a long time. These personnel were exposed to long-term radiation and non-radiation factors of the production environment, as well as stress and other factors. These factors could result in negative changes of health.

COMPLEX RADIATION AND HYGIENIC MONITORING OF POPULATION ON RADIOLOGICALLY CONTAMINATED TERRITORIES OF ZHYTOMYR OBLAST IN 2021.

Objective: the key factors identification in radiation dose formation in population of radiologically contaminatedareas of Zhytomyr oblast in the current period of accident through complex radiation and hygienic monitoring in reference settlements in 2021.

Materials And Methods: For complex radiationhygienic monitoring in Zhytomyr oblast, 10 settlements were chosen - Narodychi, Selets, Bazar, Rudnya Bazarska, Khrystynivka - zone 2, Motiyki, Zalissya, Davydky, Radcha, Nova Radcha - zone 3 of Narodychi district, in which the highest radiation doses were recorded after the accident at the Chornobyl Nuclear Power Plant. The research was carried out in June 2021.

ASSESSMENT OF QUALITATIVE CHANGES IN PERIPHERAL BLOOD CELLS IN CHILDREN - RESIDENTS OF RADIOLOGICALLY CONTAMINATED TERRITORIES IN THE LATE PERIOD AFTER THE ChNPP ACCIDENT.

Objective: to establish the relationship between quantitative and qualitative parameters of peripheral blood cells(lymphocytes, neutrophilic granulocytes, monocytes, platelets) depending on the type of somatic diseases andannual internal radiation doses from 137Cs in children - residents of radiologically contaminated territories in thelate period after the Chornobyl Nuclear Power Plant (ChNPP) accident.

Materials And Methods: There were 175 children included in the study comprising residents of radiologically con-taminated territories (n = 79) aged from 4 to 18 years. Annual internal radiation doses in children from 137Cs rangedfrom 0.

RECONSTRUCTION, VERIFICATION AND ANALYSIS OF RESULTS OF WBC MEASUREMENTS DATED 1986 THAT WERE INPUTTED TO ELECTRONIC DATABASE IN 2019-2021.

Unlabelled: Objective of research is to improve the electronic database of WBC measurements dated 1986 by inputting of newinformation from paper carriers, reconstruction of information gaps, verification and analysis of new entered data,revision of internal exposure doses that are based on results of WBC measurements dated 1986.

Materials And Methods: In 2013-2015 during a revision of databases (DB) of WBC measurements results dated1986-2014, it was discovered a great amount of paper carriers with information about WBC measurements, includ-ing the ones dated 1986, that were not inputted to the electronic DB. The paper carriers were systematized andordered by the following indicators: place of residence of a person and place of WBC measurement, institution andoperator that made the measurement, measurement device and date of measurement.

COMPREHENSIVE RADIATION AND HYGIENIC MONITORING IN POPULATION OF THE RIVNE OBLAST RADIOLOGICALLY CONTAMINATED TERRITORIES.

Objective: The key factors identification in radiation dose formation in population of radiologically contaminatedareas of Rivne oblast in the current period of accident through comprehensive radiation and hygienic monitoring inreference settlements in 2020 and estimation of their impact on dose formation were the study objectives.

Materials And Methods: Comprehensive radiation and hygienic monitoring of settlements in Rivne oblast(province) was provided in Stare Selo, Vezhytsia, Perekhodychi, and Drozdyn villages of Rokytne district, where thehighest radiation doses were registered after the ChNPP accident. Studies were conducted in September 2020.

ENDOCRINE REGULATION OF ERYTHROID LINEAGE OF HEMATOPOIESIS IN CHILDREN LIVING UNDER A LOW-DOSE RADIATION EXPOSURE AFTER THE CHORNOBYL NPP ACCIDENT.

Objective: Elucidation of relationship between the levels of thyroid-stimulating hormone (TSH), free serum thyroxine, serum and urine cortisol and parameters of erythroid lineage of hematopoiesis to estimate the thyroid functionin children of prepubertal, pubertal, and postpubertal age permanently residing under a low-dose radiation exposureto determine the premorbid state of thyroid function.

Materials And Methods: Children aged 3 to 18 years old (n = 203) living in the most intensively radionuclide-contaminated regions of Kyiv, Zhytomyr and Chornihiv oblasts of Ukraine after the Chornobyl NPP accident wereenrolled. Complaints of ossalgia, arthralgia, fatigue, bone fractures in the history, bone dysembryogenetic stigmata,hypermobility syndrome degree, and types of somatic diseases were taken into account.

COMPREHENSIVE RADIOLOGICAL AND HYGIENIC MONITORING OF PARTICULAR SETTLEMENTS OF KYIV REGION IN 2019.

Objective: to identificate the main factors and assess their impact on the formation of radiation doses to the population of radioactively contaminated areas of Kyiv region at the current stage of the accident based on complexradiation and hygienic monitoring in the reference settlements in 2019.

Materials And Methods: Comprehensive radiological and hygienic monitoring was carried out in eight settlementsof Kyiv region - villages of Ragivka, Lygovyky, Mar'yanivka, Zelena Poliana of Polis'kyi district and villages ofHornostaipil, Dytiatky , Pisky, Karpylivka of Ivankiv district. The content of incorporated 137Cs was determined withdirect measurement on whole body counters (WBC) samples of basic foodstuffs were collected to determine the content of radionuclides 90Sr and 137Cs, residents were interviewed about the levels of consumption of these products,and work was performed to estimate external radiation doses.

RESULTS OF WBC-MONITORING OF FIREFIGHTERS PARTICIPATING IN RESPONSE TO CHORNOBYL FOREST FIRES IN APRIL-MAY 2020.

Objective: of this study was to determine the levels of radionuclides in the rescuers' bodies of the SES during firefighting in the exclusion zone of the Chornobyl nuclear power plant and to assess the dose of internal radiation dueto this receipt.

Materials And Methods: From 06.04.

EVALUATION OF MAIN FOODSTUFFS CONSUMPTION BY RESIDENTS OF PARTICULAR SETTLEMENTS ON RADIOLOGICALLY CONTAMINATED TERRITORIES OF UKRAINE.

Objective: evaluation of main foodstuffs consumption levels of residents in particular settlements on radiological- ly contaminated territories of Kyiv, Rivne and Zhytomyr regions and determination of the proportion of local house- holds products to goods purchased in the trade network in the daily ration.

Materials And Methods: The research was conducted in 22 settlements of Kyiv, Rivne, Zhytomyr regions. For the study, the questionnaires were written for adults and children, which included 47 questions in 5 content blocks regarding the questionnaire data of the interviewed person; peculiarities of household management; levels of food consumption grown in local households and separately purchased in the trade network; levels of local wildlife products consumption; and the fifth - regarding the possession of information on radiation, received an individual dose of radiation from the «Chornobyl component», protective preventive measures.

MORPHOMETRIC PARAMETERS OF RETINAL MACULAR ZONE IN RECONVALESCENTS OF ACUTE RADIATION SICKNESS (IN REMOTE PERIOD).

Objective: evaluate the retinal morphometric parameters of the reconvalescents in remote period after acute radi-ation sickness.

Materials And Methods: A complete ophthalmologic examination was carried out on 7 reconvalescents of acuteradiation sickness. The examined are divided into two subgroups: 1) patients with macular degeneration of the reti-na (8 eyes); 2) patients without clinical signs of macular pathology (6 eyes).

FEATURES OF NITRIC OXIDE METABOLISM AND RISK OF DEVELOPING ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH e-NOS GENE 4a/4b POLYMORPHISM UNDER LONG-TERM ENTERING 137Cs TO BODY.

Objective: To determine the features of the nitrogen oxide metabolism and risk of developing endothelial dysfunc-tion in children with e-NOS 4a/4b gene polymorphism, who live under prolonged enter 137Cs to the body.

Materials And Methods: There were examined 117 children-residents of radioactively contaminated territories and50 children of control group. The level of stable metabolites was defined in blood serum (NO2- and NO3-).

RESULTS OF COMPREHENSIVE RADIOLOGICAL - HYGIENIC MONITORING IN SOME SETTLEMENTS OF RADIOLOGICALLY CONTAMINATED AREAS IN RIVNE REGION IN 2017.

Objective: Identification of the main factors of radiation exposure formation in the residents of surveyed settle-ments of radiologically contaminated territories in Rivne region and estimation of radiation doses in population ata current stage of the accident.

Materials And Methods: Comprehensive radiological and hygienic monitoring was conducted within 7 settlementsof the Rokytnivsky district of Rivne region, namely in the Stare Selo, Vezhytsya, Perehodychi, Drozdyn', Berezove,Zabolottya, and Hrabun' villages. Assay of the incorporated 137Cs was held using a whole-body counter in residentsof the villages twice a year, i.

RESULTS OF WBC MEASUREMENTS WERE MADE AT RADIOACTIVELY CONTAMINATED TERRITORIES OF UKRAINE IN 1986-2014 (REVISION AND ANALYSIS).

Objective: revision, analysis, and significant improvement of quality of the database of WBC measurements made in1986-2014 at radioactively contaminated territories of Ukraine by the use of renewal of informational gaps andimprovement of the model for assessment of internal exposure doses.

Materials And Methods: Inthe periodfrom 1986 to 2014 experts of the Whole Body Counters Laboratory of NRCRMaccumulated about 1.5 million results of WBC measurementsof radio-cesium incorporated in the body of personsresiding at the territories which are radioactively contaminated due to Chornobyl accident.

Reconstruction of individualized doses of subjects from the Ukrainian State Register - of Persons that Affected due to Chornobyl accident and reside in Korosten raion of Zhytomyr oblast.

Study Objective: To elaborate an ecological dosimetric model of reconstruction individualized exposure doses of subjects from the State Register of Ukraine (SRU) - of persons, affected due to Chornobyl accident and reside at the radioactive contaminated territory of Korosten raion of Zhytomyr Oblast, and to calculate exposure doses for those persons.

Materials And Methods: In the paper, an ecological dosimetric model is presented which is elaborated in order to individualize exposure doses of people who reside in Korosten raion of Zhytomyr Oblast and are registered in SRU. The model is based on the results of radio ecological and dosimetric monitoring held in the period of 1986-2013 at the territory of northern oblasts of Ukraine.

Main internal dose forming factors for inhabitants of contaminated regions at current phase of the Chernobyl nuclear power plant accident (Kyiv region as an example).

Unlabelled: Objective of this work is revealing of main dose forming factors of internal doses for inhabitants of contaminated regions of Kyiv region relying on the results of integral dosimetric monitoring.

Materials And Methods: Three villages have been chosen for the investigation. They are: Raghivka, Zelena Poliana (Poliske district), Karpylivka (Ivankiv district).

Changes in stable metabolites of nitric oxide in children-residents of radioactively contaminated territories.

Objective. An evaluation of the changes in nitric oxide system by the level of its stable metabolites in the blood serum and their comparison with content of 137Сs in the body of children-residents of radioactively contaminated territories. Materials and methods.

Peculiarities of internal radiation doses due to ¹³⁷Cs and ⁹⁰Sr intake in population from Zhytomyr oblast in a late period after the Chornobyl NPP accident.

Study Objective: To reveal the peculiarities of internal radiation doses in the inhabitants of Zhytomyr oblast and to provide a scientific ground for arrangements on internal irradiation dose reducing in population from contaminated regions in long-term period after the ChNPP accident.

Materials And Methods: Comprehensive radiation monitoring was carried out in 4 settlements in Narodychi region of Zhytomyr oblast. The radiochemical, dosimetric methods (instrumental and numerical) were used in the study.

Way to improve the radiation hygenic monitoring on contaminated territories.

Study Objective: To provide an effective radiation hygienic inspection and population protection from ionizing radiation in the late period after the Chornobyl NPP (ChNPP) accident within reforming of the state sanitary & epidemiological supervision services.

Materials And Methods: The radiation hygienic monitoring (RHM) is performed in Ukraine within the scope of state sanitary & epidemiologic supervision by 158 radiological subdivisions of the sanitary & epidemiological station (SES). The structure of these subdivisions has been created taking into account the territorial regional bounds, a presence of radiological supervision services and ChNPP accident consequences.