Publications by authors named "Vasundhara Tamankar"
Front Immunol
December 2019
Article Synopsis
- Severe Combined Immunodeficiency (SCID) is a critical primary immunodeficiency disorder marked by weak immune response, with a study of 57 Indian patients revealing symptoms like recurrent pneumonia and failure to thrive predominantly appearing in infants under 6 months.
- Hematopoietic Stem Cell Transplantation (HSCT) is the only effective treatment, though only four patients in the study received it, resulting in poor survival rates, and a significant 63% of patients exhibited lymphopenia.
- Genetic analysis revealed a diverse array of mutations contributing to SCID, with 32 novel variants identified, while 14% of cases remained uncharacterized despite advanced sequencing techniques; most cases involved T
