Publications by authors named "Vasundhara R Tiku"

The factors (environmental and genetic) contributing to basal cell carcinoma (BCC) pathogenesis are well-established; however, effective agents for BCC prevention are marred by toxic side-effects. Herein, we assessed the efficacy of flavonolignan silibinin against ultraviolet B (UVB)-induced BCC in Ptch+/- (heterozygous patched homolog 1 gene) mouse model. Both male and female Ptch+/- mice were irradiated with a 240 mJ/cm2 UVB dose 3 times/week for 26 or 46 weeks, with or without topical application of silibinin (9 mg/200 µl in acetone, applied 30 min before or after UVB exposure).

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Article Synopsis
  • The study investigates the genetic diversity of G9 rotavirus strains, focusing on the VP7 gene, comparing strains from various geographical regions collected between 1987 and 2016.
  • Recent G9 strains from Himachal Pradesh and Delhi (2013-2016) show a distinct clustering in a separate lineage (III) compared to the vaccine strain 116E, which belongs to lineage-II.
  • Notable amino acid changes, including a new mutation (K143M) in neutralization epitopes, could potentially affect the effectiveness of the Rotavac® vaccine due to the evolution of these G9 strains in India.
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Acute gastroenteritis due to Rotavirus (RV) infection is a major cause of morbidity and mortality in infants and young children worldwide. In India, around 0.1 million death reported annually due to RV illness.

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Background: Group C Rotavirus (RVC) is an enteric pathogen responsible for acute gastroenteritis in children and adults globally. At present there are no surveillance studies on group C Rotaviruses in India and therefore their prevalence in India remains unknown. The present study aimed to evaluate group C rotavirus infection among <5 years old children hospitalized with acute gastroenteritis in New Delhi.

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Rotavirus is the leading cause of severe gastroenteritis in young children worldwide and is responsible for around 100,000 deaths in India annually. Vaccination against rotavirus (RV) is a high priority: 'ROTAVAC' an indigenous vaccine will soon be licensed in India. Surveillance to determine the impact of vaccines on emerging RV strains is required.

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