Global proteomics reveals pathways of mesenchymal stem cells altered by Mycobacterium tuberculosis.

Mycobacterium tuberculosis (M. tb) has a remarkable ability to persist inside host cells. Several studies showed that M.

ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis.

Triple-negative breast cancer (TNBC) has profound unmet medical need globally for its devastating clinical outcome associated with rapid metastasis and lack of targeted therapies. Recently, lipid metabolic reprogramming especially fatty acid oxidation (FAO) has emerged as a major driver of breast cancer metastasis. Analyzing the expression of major FAO regulatory genes in breast cancer, we found selective overexpression of acyl-CoA synthetase 4 (ACSL4) in TNBC, which is primarily attributed to the absence of progesterone receptor.

Investigating the differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy.

Lamins form a proteinaceous meshwork as a major structural component of the nucleus. Lamins, along with their interactors, act as determinants for chromatin organization throughout the nucleus. The major dominant missense mutations responsible for autosomal dominant forms of muscular dystrophies reside in the Ig fold domain of lamin A.

Numerical analysis on the fate and transport of TiO nanoparticles in fractured porous media: Addressing intrinsic heterogeneities in sorptive mass transfer.

The aggregation and slow migration of nanoparticles in aqueous media have caused serious concerns about their fate and impacts in the subsurface environment. Anthropogenic release and distribution of TiO nanoparticles (TNP) have immense potential for surface adsorption, occlusion, impregnation, bioaccumulation, and phase partition into various environmental compartments, and the actual risks in their interactions are still unknown. In an attempt to realize the extent of source zone migration of TNP in a fracture-skin-matrix (F-S-M) medium, a numerical model is developed and analyzed for sensitivity of certain features of the flow field.

Inhibitory effects of Gracilaria edulis and Gracilaria salicornia against the MGMT and VEGFA biomarkers involved in the onset and advancement of glioblastoma using in silico and in vitro approaches.

Glioblastoma (GBM), an aggressive primary brain tumor originating from glial cells, poses significant treatment challenges due to its rapid growth and invasiveness. The exact mechanisms of GBM's brain damage remain unclear. This study examines primary molecular markers commonly assessed in GBM patients, including brain-derived neurotrophic factor (BDNF), platelet-derived growth factor receptor A (PDGFRA), O-methylguanine DNA methyltransferase (MGMT), epidermal growth factor receptor (EGFR), and vascular endothelial growth factor A (VEGFA) using computational approaches.

Evaluation of lamin A/C mechanotransduction under different surface topography in LMNA related muscular dystrophy.

Most of the single point mutations of the LMNA gene are associated with distinct muscular dystrophies, marked by heterogenous phenotypes but primarily the loss and symmetric weakness of skeletal muscle tissue. The molecular mechanism and phenotype-genotype relationships in these muscular dystrophies are poorly understood. An effort has been here to delineating the adaptation of mechanical inputs into biological response by mutant cells of lamin A associated muscular dystrophy.

UBR7 in concert with EZH2 inhibits the TGF-β signaling leading to extracellular matrix remodeling.

The intricate interplay between resident cells and the extracellular matrix (ECM) profoundly influences cancer progression. In triple-negative breast cancer (TNBC), ECM architecture evolves due to the enrichment of lysyl oxidase, fibronectin, and collagen, promoting distant metastasis. Here we uncover a pivotal transcription regulatory mechanism involving the epigenetic regulator UBR7 and histone methyltransferase EZH2 in regulating transforming growth factor (TGF)-β/Smad signaling, affecting the expression of ECM genes.

Modification of bentonite with black cotton soil and carboxyl methyl cellulose for the enhancement of hydraulic performance of geosynthetic clay liners.

Geosynthetic clay liners (GCLs) are mostly used as flow barriers in landfills and waste containments due to their low hydraulic conductivity to prevent the leachate from reaching the environment. The self-healing and swell-shrink properties of soft clays (expansive soils) such as bentonite enable them as promising materials for the GCL core layers. However, it is important to modify their physico-chemical properties in order to overcome the functional limitations of GCL under different hydraulic conditions.

The case for screening for diabetes distress, depression, anxiety.

Our goal was to determine the prevalence of anxiety and depression in a sample of U.S. military veterans with type 2 diabetes and elevated diabetes distress (DD).

Mitigation of quorum sensing mediated virulence factors of : the role of Meldrum's acid activated furan.

The rapid emergence of drug resistant pathogens is a major threat which has warranted the development of alternative strategies to combat infectious diseases. In this work, we have tested the anti-virulent activity of Meldrum's acid activated furan (MAF) and 1,3-dimethyl barbituric acid activated furan (BAF) against and . It was found that MAF significantly reduced the violacein production and biofilm formation of at sub-inhibitory concentrations.

Emphatic information on bone mineral loss using quantitative ultrasound sonometer for expeditious prediction of osteoporosis.

Osteoporosis (OP) and osteoarthritis (OA) are skeletal disorders characterized by a reduction in bone density and quality, resulting in increased fragility and susceptibility to fractures. These illnesses are exhibiting a higher prevalence among both males and females. Fracture risk is determined by using the BMD score (Bone Mineral Density).

The impact of veteran support and resources for diabetes (iNSPiRED) on diabetes distress: Results from a randomized, parallel-group trial.

Objective: The primary objective of this research was to assess the impact of a novel, peer-directed intervention (iNSPiRED) on diabetes distress (DD) among veterans with type 2 diabetes and DD. Secondary objectives were to assess iNSPiRED's impact on anxiety, depression, and diabetes self-management behaviors.

Method: A single-blinded, randomized, parallel-group trial was conducted.

A quadruplet 3-D laser scribed graphene/MoS functionalised N-doped graphene quantum dots and lignin-based Ag-nanoparticles for biosensing.

Troponin I is a protein released into the human blood circulation and a commonly used biomarker due to its sensitivity and specificity in diagnosing myocardial injury. When heart injury occurs, elevated troponin Troponin I levels are released into the bloodstream. The biomarker is a strong and reliable indicator of myocardial injury in a person, with immediate treatment required.

Shelf-life, bioburden, water and oxygen permeability studies of laser welded SEBS/PP blended polymer.

The most common material used for blood bags is PVC, which requires the addition of DEHP to increase its flexibility. DEHP is known to cross the polymer barrier and move into the stored blood and, ultimately, the patient's bloodstream. In this work, an alternative prototype composed of SEBS/PP was fabricated through blow-moulding and compared with the commercially available PVC-based blood bag which was designated as the control.

Segmentation of Ocular Thermogram Using Level-set Algorithm for Analysis of Contralateral Portions in Healthy Eyes.

Objective: This work aimed to evaluate the level set segmentation algorithm on ocular surface thermograms. In addition, the vascularity functioning between the contralateral portions of two eyes (right and left) was identified using statistical analysis methods.

Methods: A total of 25 healthy participants with an average age of 35 years (20 men and 5 women) were selected in April 2022.

Three-amino acid loop extension homeodomain proteins regulate stress responses and encystation in Entamoeba.

It is interesting to identify factors involved in the regulation of the encystation of Entamoeba histolytica that differentiate trophozoites into cysts. Evolutionarily conserved three amino acid loop extension (TALE) homeodomain proteins act as transcription factors and execute a variety of functions that are essential for life. A TALE homeodomain (EhHbox) protein-encoding gene has been identified in E.

miRNA-mRNA Network in PBMCs of PCOS Women Identifies Overactivated Stress-Activated Kinases.

Background/aims: Earlier studies have revealed the miRNAs and mRNAs involved in Polycystic Ovarian Syndrome (PCOS), but little is known about their regulatory networks.

Methods: To address this issue, we applied a comprehensive miRNA, mRNA profiling approach in peripheral blood of PCOS patients. We identified 30 differential miRNAs and 3310 differential transcripts.

CGM Metrics Identify Dysglycemic States in Participants From the TrialNet Pathway to Prevention Study.

Objective: Continuous glucose monitoring (CGM) parameters may identify individuals at risk for progression to overt type 1 diabetes. We aimed to determine whether CGM metrics provide additional insights into progression to clinical stage 3 type 1 diabetes.

Research Design And Methods: One hundred five relatives of individuals in type 1 diabetes probands (median age 16.

Glandular trichome specificity of menthol biosynthesis pathway gene promoters from Mentha × piperita.

Several cis-elements including Myb-binding motifs together confer glandular trichome specificity as revealed from heterologous expression and analysis of menthol biosynthesis pathway gene promoters. Glandular Trichomes (GTs) are result of division of epidermal cells that produce diverse metabolites. Species of mint family are important for their essential oil containing many high-value terpenoids, biosynthesized and stored in these GTs.

A Comprehensive Review on Biopolymer Mediated Nanomaterial Composites and Their Applications in Electrochemical Sensors.

Biopolymers are an attractive green alternative to conventional polymers, owing to their excellent biocompatibility and biodegradability. However, their amorphous and nonconductive nature limits their potential as active biosensor material/substrate. To enhance their bio-analytical performance, biopolymers are combined with conductive materials to improve their physical and chemical characteristics.

Performance evaluation of grid-connected photovoltaic system for Kuttiady village in Kerala, India.

To combat the adverse environmental effects of fossil fuel burning for power generation and to conserve it for strategic use, new, clean, and renewable energy sources are being utilized for power generation. The study presents techno-economic analysis of a grid-connected solar photovoltaic (PV) power plant to partially meet the energy consumption of the people of Kuttiady village in Kerala, India. The proposed 2315.

Nitrate transport in a fracture-skin-matrix system under non-isothermal conditions.

Subsurface leaching of agricultural runoff has been identified to pose a serious hazard to the soil-water ecosystem and human health, mostly due to the associated contamination with nitrate. Our understanding of the nature of contaminant spread in the vadose and aquifer zones has been improved from recent mechanistic models on the flow and transport of contaminants through fractured porous media. The present study aims to explore the impacts of skin formation in a fracture-matrix aquifer system onto the nitrogen species transport under non-isothermal settings using numerical modeling.